Sumo 2/3 Antibody (YA6999)
(Synonyms: HSMT3 antibody; MGC117191 antibody; OTTHUMP00000115275 antibody; OTTHUMP00000115276 antibody; OTTHUMP00000115277 antibody; Sentrin 2 antibody; Small ubiquitin like modifier 2 antibody; Small ubiquitin related modifier 2 antibody; small ubiquitin-like modifier 3 antibody; small ubiquitin-related modifier 3 antibody)
Based on 1 Customer Validation
Sumo 2/3 Antibody (YA6999) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sumo 2+3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P, IHC-F, ICC/IF, IF-Tissue, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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FC
FC: Flow Cytometry
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|---|---|---|---|---|---|
| Dilution Ratio | 1:50-200 | 1:50-200 | 1:50-200 | 1:50-200 | 1:50-100 |
Product Details
Sumo 2/3 Antibody (YA6999) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sumo 2+3.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 16kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 11-12kDa
A synthesized peptide derived from human Sumo 2. The exact sequence is proprietary to MCE.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Sumo 2/3 is an Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX[1][2][3][4].
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Subcellular Localization
Cytoplasm,Nucleus,Nucleus, PML body
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Expression
Tissue_Specificity: Expressed predominantly in liver -
Isoforms & Post-Translational Modification
P55854 has two isomers: P55854-1: 11637 Da (predicted); P55854-2: 15768 Da (predicted).
Polymeric chains can be formed through Lys-11 cross-linking丨Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function -
Subunit
Covalently attached to a number of proteins
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SwissProt ID
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Synonyms
HSMT3 antibody; MGC117191 antibody; OTTHUMP00000115275 antibody; OTTHUMP00000115276 antibody; OTTHUMP00000115277 antibody; Sentrin 2 antibody; Small ubiquitin like modifier 2 antibody; Small ubiquitin related modifier 2 antibody; small ubiquitin-like modifier 3 antibody; small ubiquitin-related modifier 3 antibody
Documentation
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