SYT1 Antibody (YA7119)(PBS only)
(Synonyms: SVP65, SYT, SYT1, Synaptotagmin-1, Synaptotagmin I, p65, SytI)SYT1 Antibody (YA7119) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYT1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, FC, ELISA
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Reactivity :
Human, Mouse, Rat, Rabbit
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
SYT1 Antibody (YA7119) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYT1.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat, Rabbit
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Calculated Molecular Weight Predicted band size: 48kDa;
Purified recombinant fragment of SYT1 expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SYT1 is a Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes[1].
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Subcellular Localization
Cytoplasmic vesicle, secretory vesicle membrane,Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane,Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane,Cytoplasm
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Expression
Tissue_Specificity: Expressed in melanocytes (PubMed:23999003) -
Isoforms & Post-Translational Modification
P21579: 422 amino acids, molecular weight 47573 Da.
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Subunit
Homotetramer (Probable)
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SwissProt ID
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Synonyms
SVP65, SYT, SYT1, Synaptotagmin-1, Synaptotagmin I, p65, SytI
Documentation
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