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  4. Monoclonal Antibodies Recombinant Antibodies
  5. T Box Protein 3 Antibody (YA2154)

T Box Protein 3 Antibody (YA2154)

Art. -Nr.: HY-P82409
User Guide for Antibodies Technical Support

T Box Protein 3 Antibody (YA2154) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to T Box Protein 3.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Beschreibung

Beschreibung

T Box Protein 3 Antibody (YA2154) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to T Box Protein 3.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molekulargewicht
Predicted band size: 79 kDa;
Observed band size: 79 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Mouse
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human Tbx3
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Reinheit Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Background
Function：Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537)
Subcellular Localization：Nucleus
Expression：
Tissue_specificity:Widely expressed
Isoforms & Post-Translational Modification：O15119 has 4 isomers: O15119-1: 79389 Da (predicted); O15119-2: 77178 Da (predicted); O15119-3: 65604 Da (predicted); O15119-4: Da (predicted).
Subunit：Interacts with PML (isoform PML-4)
Database

Entrez Gene: 21386 Mouse

SwissProt: P70324 Mouse

Research Field

Epigenetics and Nuclear Signaling
Synonyms
T box 3; T-box protein 3; Tbx3; TBX3 ISO; UMS; XHL
Dokumentation
User Guide for Antibodies (1077 KB)

T Box Protein 3 Antibody (YA2154) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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T Box Protein 3 Antibody (YA2154)
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