2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. Thyroglobulin Antibody (YA5696)

Thyroglobulin Antibody (YA5696)

製品番号: HY-P86004
User Guide for Antibodies Technical Support

Thyroglobulin Antibody (YA5696) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thyroglobulin.

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容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

Thyroglobulin Antibody (YA5696) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thyroglobulin.
Host

Mouse
Clonality

Monoclonal
分子量

Predicted band size: 305 kDa;

Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Synthesized peptide derived from human Thyroglobulin AA range: 2700-2768
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:200-400
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:500-5000
純度 affinity chromatography. Conjugation Non-conjugated
Modification Unmodified Isotype IgG1
Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:17532758, PubMed:32025030). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030)
Subcellular Localization：Secreted
Expression：
Tissue_specificity:It is mainly expressed in the thyroid gland.
Isoforms & Post-Translational Modification：P01266 has 2 isomers: P01266-1: 304790 Da (predicted); P01266-2: 298383 Da (predicted).
Iodinated on tyrosine residues by TPO (PubMed:2760035, PubMed:32025030). There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-24 is coupled to donor Tyr-149 or Tyr-234, acceptor Tyr-2573 is coupled to donor Tyr-2540, acceptor Tyr-2766 in monomer 1 is coupled to donor Tyr-2766 in monomer 2 and acceptor Tyr-1310 in monomer 1 is coupled to donor Tyr-108 in monomer 2 (PubMed:32025030);Sulfated tyrosines are desulfated during iodination;Undergoes sequential proteolysis by cathepsins to release thyroxine (T4) and triiodothyronine (T3) hormones. In the thyroid follicle lumen, cross-linked TG (storage form) is solubilized by limited proteolysis mediated by cathepsins CTSB and/or CTSL. Partially cleaved TG is further processed by CTSK/cathepsin K and/or CTSL resulting in the release of T4. Following endocytosis, further processing occurs leading to the release of T3 and more T4 hormones
Subunit：Monomer (PubMed:32025030). Homodimer (via ChEL region); occurs in the endoplasmic reticulum and is required for export to the Golgi apparatus (PubMed:32025030). Homooligomer; disulfide-linked; stored in this form in the thyroid follicle lumen (PubMed:8626858)
Synonyms
Thyroglobulin; Tg;
ドキュメンテーション
User Guide for Antibodies (1077 KB)

Thyroglobulin Antibody (YA5696) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Thyroglobulin Antibody (YA5696)
製品番号:
HY-P86004
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