TG - thyroglobulin Gene
Also Known as TGN; AITD3
Species: Homo sapiens
About TG
This gene has 20 transcripts (splice variants), 217 orthologues, 13 paralogues and is associated with 3 phenotypes. Restricted expression toward thyroid (RPKM 4323.9).
Summary
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
TG Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_003235.5 | NP_003226.4 | thyroglobulin precursor |
| Molecular Function GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| enables identical protein binding |
IDA
IDA: Inferred from direct assay
|
8626858 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
18687776 | GOA |
| Biological Process GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| involved in thyroid gland development |
IEP
IEP: Inferred from expression pattern
|
15494458 | GOA |
| involved in thyroid hormone generation |
IDA
IDA: Inferred from direct assay
|
32025030 | GOA |
| Cellular Component GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
8626858 | GOA |
TG Protein Structure
Thyroglobulin_1: Thyroglobulin type-1 repeat (39 - 92)
Thyroglobulin_1: Thyroglobulin type-1 repeat (96 - 160)
Thyroglobulin_1: Thyroglobulin type-1 repeat (308 - 358)
Thyroglobulin_1: Thyroglobulin type-1 repeat (605 - 658)
Thyroglobulin_1: Thyroglobulin type-1 repeat (662 - 726)
Thyroglobulin_1: Thyroglobulin type-1 repeat (1023 - 1067)
Thyroglobulin_1: Thyroglobulin type-1 repeat (1091 - 1137)
Thyroglobulin_1: Thyroglobulin type-1 repeat (1159 - 1210)
Ephrin_rec_like: Putative ephrin-receptor like (1465 - 1510)
COesterase: Carboxylesterase family (2203 - 2718)
- 0
- 500
- 1000
- 1500
- 2000
- 2500
- 2768 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
thyroglobulin |
|
TG Antibodies
| Referencia número | Nombre del producto | Aplicación | Reactivity |
|---|---|---|---|
| HY-P82454 | Thyroglobulin Antibody (YA2199) | WB, IP | Human |
| HY-P86004 | Thyroglobulin Antibody (YA5696) | IHC-P, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Thyroid Dyshormonogenesis 3 |
|
|
| Autoimmune Thyroid Disease 3 |
|
|
| Congenital Hypothyroidism |
|
|
| Familial Thyroid Dyshormonogenesis |
|
|
| Goiter |
|
|
| Hypothyroidism |
|
|
| Thyroiditis |
|
|
| Papillary Carcinoma |
|
|
| Struma Ovarii |
|
|
| Hyperthyroidism |
|
|
| Nodular Goiter |
|
|
| Subacute Thyroiditis |
|
|
| Nontoxic Goiter |
|
|
| Graves' Disease |
|
|
| Hashimoto Thyroiditis |
|
|
| Follicular Adenoma |
|
|
| Toxic Diffuse Goiter |
|
|
| Plummer'S Disease |
|
|
| Multinodular Goiter |
|
|
| Endemic Goiter |
|
|
| Thyroid Crisis |
|
|
| Myxedema |
|
|
| Papillary Thyroid Microcarcinoma |
|
|
| Graves Ophthalmopathy |
|
|
| Thyroid Gland Cancer |
|
|
| Pendred Syndrome |
|
|
| Ovarian Germ Cell Teratoma |
|
|
| Malignant Struma Ovarii |
|
|
| Papillary Follicular Thyroid Adenocarcinoma |
|
|
| Thyroid Carcinoma |
|
|
| Mucoepidermoid Carcinoma |
|
|
| Thyroid Cancer, Nonmedullary, 2 |
|
|
| Thyroid Lymphoma |
|
|
| Postsurgical Hypothyroidism |
|
|
| Benign Struma Ovarii |
|
|
| Suppurative Thyroiditis |
|
|
| Benign Teratoma |
|
|
| Graves Disease 1 |
|
|
| Fetal Adenoma |
|
|
| Thyroid Gland Anaplastic Carcinoma |
|
|
| Multicentric Papillary Thyroid Carcinoma |
|
|
| Thyroid Sarcoma |
|
|
| Acute Thyroiditis |
|
|
| Subacute Lymphocytic Thyroiditis |
|
|
| Thyroid Gland Disease |
|
|
| Exophthalmos |
|
|
| Endocrine Exophthalmos |
|
|
| Thyroid Hyalinizing Trabecular Adenoma |
|
|
| Atypical Follicular Adenoma |
|
|
| Thyroid Hormone Resistance, Generalized, Autosomal Dominant |
|
|
| Tall Cell Variant Papillary Carcinoma |
|
|
| Spindle Epithelial Tumor With Thymus-Like Differentiation Tumor |
|
|
| Papillary Thymic Adenocarcinoma |
|
|
| Thyroid Carcinoma, Hurthle Cell |
|
|
| Pernicious Anemia |
|
|
| Autoimmune Disease Of Endocrine System |
|
|
| Turner Syndrome |
|
|
| Multiple Endocrine Neoplasia |
|
|
| Ovarian Germ Cell Cancer |
|
|
| Paraganglioma |
|
|
| Thyroid Angiosarcoma |
|
|
| Trabecular Follicular Adenocarcinoma |
|
|
| Hypothyroidism, Congenital, Nongoitrous, 2 |
|
|
| Substernal Goiter |
|
|
| Thyroid Carcinoma, Familial Medullary |
|
|
| Thyroid Dyshormonogenesis 2a |
|
|
| Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors |
|
|
| Type 1 Diabetes Mellitus |
|
|
| Breast Cystic Hypersecretory Carcinoma |
|
|
| Middle Ear Carcinoma |
|
|
| Thyroid Gland Follicular Carcinoma |
|
|
| Cystic Teratoma |
|
|
| Hypoadrenocorticism, Familial |
|
|
| Chronic Urticaria |
|
|
| Adenoma |
|
|
| Iodine Hypothyroidism |
|
|
| Thyroid Gland Hurthle Cell Carcinoma |
|
|
| Colloid Adenoma |
|
|
| Mechanical Strabismus |
|
|
| Nonencapsulated Sclerosing Carcinoma |
|
|
| Epithelial Malignant Thymoma |
|
|
| Thyroid Gland Medullary Carcinoma |
|
|
| Celiac Disease 1 |
|
|
| Diabetes Insipidus |
|
|
| Clear Cell Adenoma |
|
|
| Atrophic Glossitis |
|
|
| Cyclotropia |
|
|
| Thyrotoxic Exophthalmos |
|
|
| Neonatal Thyrotoxicosis |
|
|
| Hypothyroidism, Congenital, Nongoitrous, 4 |
|
|
| Euthyroid Sick Syndrome |
|
|
| Dyshormonogenic Goiter |
|
|
| Vulvar Keratinizing Squamous Cell Carcinoma |
|
|
| Immature Teratoma Of Ovary |
|
|
| Ectopic Thymus |
|
|
| Type 1 Diabetes Mellitus 5 |
|
|
| Middle Ear Adenocarcinoma |
|
|
| Adrenal Cortical Hypofunction |
|
|
| Thyroid Hormone Resistance, Selective Pituitary |
|
|
| Hypothyroidism, Congenital, Nongoitrous, 1 |
|
|
| Viral Hepatitis |
|
|
| Horner'S Syndrome |
|
|
| Thyroid Gland Mucoepidermoid Carcinoma |
|
|
| Orbital Disease |
|
|
| Dendritic Cell Thymoma |
|
|
| Ovarian Benign Neoplasm |
|
|
| Autoimmune Disease |
|
|
| Parathyroid Gland Disease |
|
|
| Chronic Spontaneous Urticaria |
|
|
| Mature Teratoma |
|
|
| Heart Leiomyosarcoma |
|
|
| Pulmonary Aspergilloma |
|
|
| Chronic Orbital Inflammation |
|
|
| Mature Teratoma Of The Ovary |
|
|
| Isthmus Cancer |
|
|
| Orbital Plasma Cell Granuloma |
|
|
| Autoimmune Gastritis |
|
|
| Autoimmune Polyendocrine Syndrome |
|
|
| Parathyroid Adenoma |
|
|
| Nasal Cavity Olfactory Neuroblastoma |
|
|
| Papillary Adenocarcinoma |
|
|
| Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 |
|
|
| Lagophthalmos |
|
|
| Carotid Body Cancer |
|
|
| Ovary Leiomyosarcoma |
|
|
| Salivary Gland Disease |
|
|
| Adrenal Cortex Disease |
|
|
| Endocrine Organ Benign Neoplasm |
|
|
| Premature Menopause |
|
|
| Ovarian Serous Cystadenofibroma |
|
|
| Immunodeficiency 58 |
|
|
| Ovarian Serous Adenofibroma |
|
|
| Diabetes Mellitus |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | TG | RGD | RGD:3848 |
| Canis familiaris | TG | VGNC | VGNC:47306 |
| Macaca mulatta | TG | VGNC | VGNC:99476 |
| Bos taurus | TG | VGNC | VGNC:35798 |
| Mus musculus | TG | MGD | MGI:98733 |
| Felis catus | TG | VGNC | VGNC:66128 |
| Others | TG | NCBI |