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Cat. No.: HY-18112

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AZ-4217

AZ-4217 is an inhibitor for β-site amyloid precursor protein cleavage enzyme 1 (BACE1), with IC₅₀ of 160 pM in human SH-SY5Y cells. AZ-4217 reduces amyloid deposition in Tg2576 mouse models, and is used for Alzheimer’s Disease research.

For research use only. We do not sell to patients.

CAS No.: 1383846-83-0
Formula: C₃₀H₂₅FN₄O
Molecular Weight:476.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

AZ-4217 Chemical Structure

CAS No.: 1383846-83-0

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Sample (0.1mg)

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Beta-secretase Isoforms :

BACE1
BACE2

Cellular Effect

Cell Line	Type	Value	Description	References
Cerebral cortex neuron	IC₅₀	2.6 nM Compound: (R)-41	Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA	[PMID: 22924815]
CHO	IC₅₀	2.8 μM Compound: (R)-41	Inhibition of human ERG expressed in CHO cells by IonWorks assay Inhibition of human ERG expressed in CHO cells by IonWorks assay	[PMID: 22924815]
SH-SY5Y	IC₅₀	0.16 nM Compound: (R)-41	Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay	[PMID: 22924815]

Chemical Information

CAS No. 1383846-83-0
Molecular Weight 476.54
Formula C₃₀H₂₅FN₄O
SMILES

O=C(C(C)=C1)N(CC)C=C1[C@@]2(C3=CC(C4=CN=CC(C#CC)=C4)=CC=C3)C5=CC=CC(F)=C5C(N)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Eketjäll S, et al., AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. J Neurosci. 2013 Jun 12;33(24):10075-84. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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