1383846-83-0
Chemical Structure
AZ-4217
- CAS No.: 1383846-83-0
- Formula:C30H25FN4O
- Molecular Weight:476.54
IUPAC Name: (R)-5-(3-amino-4-fluoro-1-(3-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one
InChIKey: TUGLMYZSOPKJOA-PMERELPUSA-N
SMILES: O=C(C(C)=C1)N(CC)C=C1[C@@]2(C3=CC(C4=CN=CC(C#CC)=C4)=CC=C3)C5=CC=CC(F)=C5C(N)=N2
Biological Activity: AZ-4217 is an inhibitor for β-site amyloid precursor protein cleavage enzyme 1 (BACE1), with IC50 of 160 pM in human SH-SY5Y cells. AZ-4217 reduces amyloid deposition in Tg2576 mouse models, and is used for Alzheimer’s Disease research[1].
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AZ-4217 | AZ-4217 is an inhibitor for β-site amyloid precursor protein cleavage enzyme 1 (BACE1), with IC50 of 160 pM in human SH-SY5Y cells. AZ-4217 reduces amyloid deposition in Tg2576 mouse models, and is used for Alzheimer’s Disease research. | |||||||||||||||||||||
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Keywords
