Enpp-1-IN-2

Cat. No.: HY-139362 Purity: 99.16%: FAQs
Data Sheet SDS COA Handling Instructions

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Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC₅₀ values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe.

For research use only. We do not sell to patients.

Enpp-1-IN-2 Chemical Structure

CAS No. : 2378640-92-5

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 248	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 248	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 960	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1520	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

IC₅₀ & Target

IC₅₀: 0.26 μM (TG-mAMP assay), 0.48 μM (pNP-TMP assay), 2.0 μM (ATP assay)^[1]

Molecular Weight

282.34

Formula

C₁₅H₁₈N₆

CAS No.

2378640-92-5

Appearance

Solid

Color

White to off-white

SMILES

CC1=NC2=NC=NN2C(N(C)C)=C1CC3=CC=CC(N)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (354.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5418 mL	17.7091 mL	35.4183 mL
5 mM	0.7084 mL	3.5418 mL	7.0837 mL
10 mM	0.3542 mL	1.7709 mL	3.5418 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.16%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (131 KB) RP-HPLC (142 KB) LCMS (384 KB)

Handling Instructions (2659 KB)

References

[1]. Kawaguchi M, et al. Development of an ENPP1 Fluorescence Probe for Inhibitor Screening, Cellular Imaging, and Prognostic Assessment of Malignant Breast Cancer. J Med Chem. 2019 Oct 24;62(20):9254-9269. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5418 mL	17.7091 mL	35.4183 mL	88.5457 mL
	5 mM	0.7084 mL	3.5418 mL	7.0837 mL	17.7091 mL
	10 mM	0.3542 mL	1.7709 mL	3.5418 mL	8.8546 mL
	15 mM	0.2361 mL	1.1806 mL	2.3612 mL	5.9030 mL
	20 mM	0.1771 mL	0.8855 mL	1.7709 mL	4.4273 mL
	25 mM	0.1417 mL	0.7084 mL	1.4167 mL	3.5418 mL
	30 mM	0.1181 mL	0.5903 mL	1.1806 mL	2.9515 mL
	40 mM	0.0885 mL	0.4427 mL	0.8855 mL	2.2136 mL
	50 mM	0.0708 mL	0.3542 mL	0.7084 mL	1.7709 mL
	60 mM	0.0590 mL	0.2952 mL	0.5903 mL	1.4758 mL
	80 mM	0.0443 mL	0.2214 mL	0.4427 mL	1.1068 mL
	100 mM	0.0354 mL	0.1771 mL	0.3542 mL	0.8855 mL

Enpp-1-IN-2 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enpp-1-IN-22378640-92-5Phosphodiesterase (PDE)malignant breast cancerInhibitorinhibitorinhibit

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Enpp-1-IN-2

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Enpp-1-IN-2 Related Antibodies

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Complete Stock Solution Preparation Table

Enpp-1-IN-2 Related Classifications

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