2. Metabolic Enzyme/Protease
  3. Glutaminase
  4. LM11

LM11 is an inhibitor of transglutaminase 2 (TG2) with an activity of killing glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.

For research use only. We do not sell to patients.

LM11 Chemical Structure

LM11 Chemical Structure

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LM11 Related Antibodies

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Description

LM11 is an inhibitor of transglutaminase 2 (TG2) with an activity of killing glioblastoma cells by maintaining TG2 in a cytotoxic conformational state[1].

In Vitro

LM11 (0.1-100 μM, 6 h) inhibits MDA-MB-231 cell migration in a dose-dependent fashion at stimulation with EGF.
LM11 (100 μM, 16 h) inhibits MDA-MB-231 cell viability with a 60% death rate.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LM11 Related Antibodies

Cell Migration Assay [2]

Cell Line: MDA-MB-231
Concentration: 0.1, 1, 10, 100 μM
Incubation Time: 6 h
Result: Inhibited cell migration at 10 uM of stimulation with EGF.
Inhibited cell viability at 100 uM after 16 h.
Molecular Weight

537.35

Formula

C26H18Cl2N4O5
SMILES

O=C1NC(N(C(/C1=C/NC2=CC(CN3C(C4=C(C3=O)CCC=C4)=O)=C(C=C2)Cl)=O)C5=CC=CC(Cl)=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LM11 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LM11LM 11LM-11GlutaminaseTG2 inhibitorglioblastoma cellsInhibitorinhibitorinhibit

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LM11
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HY-157975
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