2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. ELB041

ELB041 (AFS98) is a rat monoclonal anti-murine c-fms antibody (IgG2a). AFS98 inhibits M-CSF–dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. AFS98 prevents development of fatty streaks in ApoE-deficient mice. ELB041 can be used for the research of atherosclerosis.

For research use only. We do not sell to patients.

ELB041

ELB041 Chemical Structure

Size Stock
1 mg   Get quote  
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

ELB041 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ELB041 (AFS98) is a rat monoclonal anti-murine c-fms antibody (IgG2a). AFS98 inhibits M-CSF–dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. AFS98 prevents development of fatty streaks in ApoE-deficient mice. ELB041 can be used for the research of atherosclerosis[1].

Species Reactivity

Human
IC50 & Target

CSF1R/M-CSFR/CD115
In Vivo

ELB041 (2 mg; i.p.; alternate days; 6 weeks) prevents atheroma formation and has minimal effect on advanced lesion size in apoE−/− mice (with a suppression rate of ~70%)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Apolipoprotein E (apoE)-deficient mice (female, 6 weeks of age, hybrid 129ola x C57BL/6)[1]
Dosage: 2 mg
Administration: i.p.; alternate days; 6 weeks
Result: Suppressed macrophage-derived foam cell accumulation in the aortic root by ~70% (total aortic lesion area: 2390 ± 204 μm² vs. PBS control: ~9000 μm²). Had minimal effect on advanced lesion size (AFS98 group: 30728 ± 2248 μm² vs. PBS group: 31753 ± 17483 μm²). Did not reduce macrophage or vascular smooth muscle cell staining in lesions. Did not significantly reduce peripheral blood monocyte count or body weight.
Gene ID

1436  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ELB041 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELB041AFS98 TG3003ELB 041ELB-041AFS 98AFS-98TG3003TG 3003TG-3003c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1Rfatty streak lesion developmentcell growthc-fmsvessel wall intimahigh-fat dietatherosclerosisaortic rootapoE-deficient miceadvanced atherosclerotic lesion sizeM-CSFmacrophage-derived foam cellsmonocyte/macrophageearly atherosclerotic fatty streak formationM-CSF-dependent colony formationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ELB041
Cat. No.:
HY-P991947
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.