CSF1R - colony stimulating factor 1 receptor Gene

Also Known as FMS; CSFR; FIM2; HDLS; C-FMS; CD115; HDLS1; CSF-1R; BANDDOS; M-CSF-R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1436

About CSF1R

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,053,295-150,113,365 (from NCBI)

This gene has 10 transcripts (splice variants), 273 orthologues, 53 paralogues and is associated with 108 phenotypes. Broad expression in spleen (RPKM 68.6), placenta (RPKM 60.0) and 22 other tissues.

Summary

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017]

CSF1R Products (7)

mRNA	Protein	Name
NM_005211.4	NP_005202.2	macrophage colony-stimulating factor 1 receptor isoform a precursor
NM_001288705.3	NP_001275634.1	macrophage colony-stimulating factor 1 receptor isoform a precursor
NM_001349736.2	NP_001336665.1	macrophage colony-stimulating factor 1 receptor isoform a precursor
NM_001375321.1	NP_001362250.1	macrophage colony-stimulating factor 1 receptor isoform b
NR_109969.2
NM_001375320.1	NP_001362249.1	macrophage colony-stimulating factor 1 receptor isoform a precursor
NR_164679.1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine binding	IDA IDA: Inferred from direct assay	20504948	GOA
enables macrophage colony-stimulating factor receptor activity	IMP IMP: Inferred from mutant phenotype	7683918	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22153499	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	7683918	GOA
involved in cell-cell junction maintenance	IMP IMP: Inferred from mutant phenotype	15117969	GOA
involved in cellular response to macrophage colony-stimulating factor stimulus	IMP IMP: Inferred from mutant phenotype	7683918	GOA
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20504948	GOA
involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	7683918	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	20504948	GOA
involved in positive regulation of cell motility	IMP IMP: Inferred from mutant phenotype	15117969	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20504948	GOA
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	20829061	GOA
acts upstream of positive regulation of macrophage chemotaxis	IGI IGI: Inferred from genetic interaction	26754294	GOA
acts upstream of positive regulation of macrophage proliferation	IGI IGI: Inferred from genetic interaction	26754294	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20504948	GOA
involved in positive regulation of protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	7681396	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	20504948	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	15117969	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSF1R Protein Structure

Ig_3

Pkinase_Tyr

0
200
400
600
800
972 a.a.

Protein Preferred Names	Protein Names
macrophage colony-stimulating factor 1 receptor	CD115 antigen CSF-1 receptor FMS proto-oncogene McDonough feline sarcoma viral (v-fms) oncogene homolog macrophage colony stimulating factor I receptor proto-oncogene c-Fms

CSF1R Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CSF1R	P07333	EPHB2	Homo sapiens	P29323	Affinity Chrom	35384245
Intra	CSF1R	P07333	EPHB2	Homo sapiens	P29323	Anti Tag CoIP	35384245
Intra	CSF1R	P07333	EPHA7	Homo sapiens	Q15375	Affinity Chrom	35384245
Intra	CSF1R	P07333	CSF1	Homo sapiens	P09603	ITC	22483114
Intra	CSF1R	P07333	CSF1	Homo sapiens	P09603	BLI	22483114

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSF1R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72509	CSF1R Protein, Human (HEK293, His)	P07333-1/NP_005202.2 (I20-P517)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73510	CSF1R Protein, Human (HEK293, C-His-Avi)	P07333-1 (I20-E512)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P72949	CSF1R Protein, Human (HEK293, hFc)	P07333-1 (I20-E512)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72948	CSF1R Protein, Human (HEK293)	P07333-1/NP_005202.2 (I20-E512)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72950	CSF1R Protein, Human (HEK293, mFc)	P07333-1 (I20-P517)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75323	CSF1R Protein, Human (HEK293, His-Fc)	P07333-1 (I20-E512)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75326	CSF1R Protein, Human (271a.a, HEK293, His)	P07333-1 (I20-S290)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75327	CSF1R Protein, Human (214a.a, HEK293, His)	P07333-1 (A299-E512)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78109	CSF1R Protein, Human (Biotinylated, HEK293, His-Avi)	P07333-1 (I20-E512)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700511	CSF1R Protein, Human (HEK293, His-Flag)	P07333-1 (I20-E512)	≥ 90%, as determined by reducing SDS-PAGE.

CSF1R Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81554	CSF-1R Antibody (YA1299)	IHC-P	Human
HY-P81554A	CSF-1R Antibody (YA1299)(PBS only)	IHC-P	Human
HY-P83988	CSF-1R Antibody (YA3685)	IHC-P, ICC/IF, ELISA	Human
HY-P83988A	CSF-1R Antibody (YA3685)(PBS only)	IHC-P, ICC/IF, ELISA	Human

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Alzheimer Disease 10	Ad10 Alzheimer Disease-10 Alzheimer'S Disease 10 Alzheimer Disease, Familial, 10 Alzheimer Disease Familial 10 Alzheimer'S Disease 10, Early Onset
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Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
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Benign Giant Cell Tumor	Giant Cell Tumors
Cerebral Degeneration	Brain Degeneration Degenerative Brain Disorder
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Pigmented Villonodular Synovitis	Diffuse Giant Cell Tumor Of Tenosynovium Villous Tenosynovitis Diffuse Pigmented Villonodular Synovitis Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Localized Pigmented Villonodular Synovitis Tgct Tsgct Tenosynovial Giant Cell Tumor Tenosynovial Giant Cell Tumors Synovitis Pigmented Villonodular Synovitis, Pigmented Villonodular Fibrous Histiocytoma Of Tendon Sheath Testicular Germ Cell Tumor Chronic Haemorrhagic Villous Synovitis Pvns - [Pigmented Villonodular Synovitis] Villonodular Synovitis
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
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Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
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Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
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Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Duodenum Adenoma
Early-Onset Calcifying Leukoencephalopathy-Skeletal Dysplasia
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1	Cadasil Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Casil Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Familial Vascular Leukoencephalopathy CADASIL1 Cadasil 1 Hereditary Multi-Infarct Dementia Cadasil Syndrome Dementia, Hereditary Multiinfarct Type Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1 Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1 Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy Dementia, Hereditary Multi-Infarct Type Hereditary Dementia, Multi-Infarct Type Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1 Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant Dementia Hereditary Multiinfarct Type Dementia Hereditary Multi-Infarct Type Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy
Csf1r-Related Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia	Csf1r-Related Alsp
Dysosteosclerosis
Tenosynovial Giant Cell Tumor	Fibrous Histiocytoma Of Tendon Sheath Giant Cell Tumor Of Tendon Sheath Giant Cell Tumor Of Tenosynovium Giant Cell Tumour Of Tendon Sheath Giant Cell Tumour Of Tenosynovium Tenosynovial Giant Cell Tumour Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Pigmented Villonodular Synovitis Tgct Tsgct
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Bone Benign Neoplasm
Nodular Tenosynovitis	Synovioma, Benign Benign Synovioma Benign Tumor Of Synovium Localized Giant Cell Tumor Of Tenosynovium Giant Cell Tumor Of Tendon Sheath
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1	Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia Hereditary Diffuse Leukoencephalopathy With Spheroids Alsp Gpsc Subcortical Gliosis Of Neumann Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids Hdls HDLS1 Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia Gliosis, Familial Progressive Subcortical Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1 Leukoencephalopathy, Diffuse Hereditary, With Spheroids Pold Pigmentary Orthochromatic Leukodystrophy Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia Familial Progressive Subcortical Gliosis Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant Dementia, Familial, Neumann Type Adult-Onset Leukodystrophy With Neuroaxonal Spheroids Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids Neuroaxonal Leukodystrophy Fpsg Familial Dementia, Neumann Type Familial Dementia Neumann Type Leukoencephalopathy, Diffuse Hereditary, With Spheroid
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis	BANDDOS
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Histiocytic Sarcoma	Malignant Histiocytosis
Acute Myelomonocytic Leukemia	Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16 16)(P13 Q22) Aml M4 Ammol Acute Myeloblastic Leukemia Type 4 Aml With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16 16)(P13 Q22) Aml-M4 Aml With Inv(16)(P13.1q22) Or T(16 16)(P13.1 Q22) Cbfb-Myh11 Leukemia Myelomonocytic Acute Acute Myelomonocytic Leukaemia Without Mention Of Remission Myelomonocytic Leukaemia Nos
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Fibrosarcoma Of Bone	Malignant Histiocytosis Malignant Fibroxanthoma Malignant Fibrous Histiocytoma Histiocytic Medullary Reticulosis Nasal Type Extranodal Nk/T-Cell Lymphoma Histiocytic Sarcoma
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16749	Pexidartinib		99.64%	Yes
HY-16749A	Pexidartinib hydrochloride		99.82%	Yes
HY-12297	Sulfatinib	Inhibitor	99.52%	Unkown

Clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50905	Dovitinib	Inhibitor	99.88%	Phase 3
HY-153920	Pimicotinib	Inhibitor	99.92%	Phase 3
HY-145601	Tinengotinib	Inhibitor	99.57%	Phase 3
HY-124526	Chiauranib	Inhibitor	98.97%	Phase 3
HY-12768A	Sotuletinib hydrochloride	Inhibitor	99.43%	Phase 2
HY-109190	Seralutinib	Inhibitor	99.94%	Phase 2
HY-109086	Edicotinib	Inhibitor	99.68%	Phase 2
HY-19772	GSK3117391	Inhibitor	99.40%	Phase 2
HY-136362	ARRY-382	Inhibitor	99.95%	Phase 2
HY-152830A	Adrixetinib TFA		99.82%	Phase 2
HY-12768B	Sotuletinib dihydrochloride	Inhibitor	/	Phase 2
HY-109086A	Edicotinib hydrochloride	Inhibitor	/	Phase 2
HY-114153	PLX5622	Inhibitor	99.95%	Phase 1
HY-114153A	PLX5622 hemifumarate	Inhibitor	99.93%	Phase 1
HY-100491	H3B-6527	Inhibitor	98.0%	Phase 1
HY-111787	Elzovantinib	Inhibitor	99.93%	Phase 1
HY-101768	PRN1371	Inhibitor	99.78%	Phase 1
HY-10204	OSI-930		98.33%	Phase 1

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99245	Emactuzumab	Inhibitor	97.60%	Phase 3
HY-P990043	Iluzanebart		98.63%	Phase 2
HY-P99452	Axatilimab	Inhibitor	99.59%	Phase 2
HY-P99259	Cabiralizumab	Inhibitor	99.73%	Phase 2
HY-P99368	Lacnotuzumab	Inhibitor	99.9%	Phase 2
HY-P991048	AMG-820	Inhibitor	98%	Phase 2

Pre-clinical Phase

Bioactive Molecules (61)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114153C	PLX5622 in AIN-76A Diet (1200 ppm)	Inhibitor	/	Unkown
HY-12768	Sotuletinib	Inhibitor	99.97%	Unkown
HY-132166	Velzatinib	Inhibitor	99.40%	Unkown
HY-10408	Ki20227	Inhibitor	99.51%	Unkown
HY-159838	Enrupatinib	Inhibitor	98.90%	Unkown
HY-161025	SYHA1813	Inhibitor	99.46%	Unkown
HY-101774	CSF1R-IN-1	Inhibitor	98.04%	Unkown
HY-159108	AZ683	Inhibitor	98.57%	Unkown
HY-117244	AZD7507	Inhibitor	99.57%	Unkown
HY-147615	CSF1R-IN-12		98.75%	Unkown
HY-122906	JTE-952	Inhibitor	99.86%	Unkown
HY-152830	Adrixetinib		99.55%	Unkown
HY-126297	c-Fms-IN-10	Inhibitor	98.63%	Unkown
HY-139990	CSF1R-IN-3	Inhibitor	98.10%	Unkown
HY-112451	cFMS Receptor Inhibitor II	Inhibitor	99.88%	Unkown
HY-132935	BPR1R024	Inhibitor	98.50%	Unkown
HY-160842	CSF1R-IN-24	Inhibitor	98.10%	Unkown
HY-117273	AZ304	Inhibitor	99.77%	Unkown
HY-119942	c-Fms-IN-8	Inhibitor	99.50%	Unkown
HY-101526	GENZ-882706	Inhibitor	/	Unkown
HY-13075	c-Fms-IN-3	Inhibitor	98.83%	Unkown
HY-132935A	BPR1R024 mesylate	Inhibitor	/	Unkown
HY-RS03228	CSF1R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-13493	AC710	Inhibitor	99.13%	Unkown
HY-13496	JNJ-28312141	Inhibitor	/	Unkown
HY-101034	CHMFL-ABL/KIT-155		/	Unkown
HY-174366	JMC14	Inhibitor	/	Unkown
HY-13496A	JNJ-28312141 hydrochloride	Inhibitor	/	Unkown
HY-144040	CSF1R-IN-4		/	Unkown
HY-144041	CSF1R-IN-5	Inhibitor	/	Unkown
HY-144042	CSF1R-IN-6		/	Unkown
HY-147608	CSF1R-IN-7	Inhibitor	/	Unkown
HY-147609	CSF1R-IN-8	Inhibitor	/	Unkown
HY-147610	CSF1R-IN-9	Inhibitor	/	Unkown
HY-147611	CSF1R-IN-10	Inhibitor	/	Unkown
HY-147616	CSF1R-IN-13		/	Unkown
HY-147617	CSF1R-IN-14		/	Unkown
HY-153012	Axl/Mer/CSF1R-IN-1	Inhibitor	/	Unkown
HY-153243	IACS-9439	Inhibitor	/	Unkown
HY-153277	Axl/Mer/CSF1R-IN-2	Inhibitor	/	Unkown
HY-153920A	Pimicotinib hydrochloride	Inhibitor	/	Unkown
HY-155001	CSF1R-IN-15	Inhibitor	/	Unkown
HY-155550	CSF1R-IN-17	Antagonist	/	Unkown
HY-157422	CSF1R-IN-19	Inhibitor	/	Unkown
HY-157996	CSF1R-IN-21	Inhibitor	/	Unkown
HY-158050	PXB17	Inhibitor	/	Unkown
HY-158148	CSF1R-IN-23	Inhibitor	/	Unkown
HY-158363	CSF1R-IN-25	Inhibitor	/	Unkown
HY-161084	CSF1R-IN-18	Inhibitor	/	Unkown
HY-162309	CSF1R-IN-20	Inhibitor	/	Unkown
HY-162415	CSF1R-IN-22		/	Unkown
HY-168954	CSF1R-IN-26		/	Unkown
HY-176194	Antifibrotic agent 1		/	Unkown
HY-183569	CSF1R-IN-27	Inhibitor	/	Unkown
HY-183931	NPA101.3	Inhibitor	/	Unkown
HY-RS03229	Csf1r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03230	Csf1r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-13493A	AC710 Mesylate	Inhibitor	/	Unkown
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	Unkown
HY-164529	SJ-C1044	Inhibitor	98.63%	Unkown
HY-174606	Human IL34 mRNA		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990125	Anti-Mouse CSF1R/CD115 Antibody (AFS98)		99.38%	Unkown
HY-P990849	Anti-CSF1R/CD115 Antibody (2-4A5-4)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CSF1R	VGNC	VGNC:27754
Mus musculus	CSF1R	MGD	MGI:1339758
Rattus norvegicus	CSF1R	RGD	RGD:2425
Macaca mulatta	CSF1R	VGNC	VGNC:71514
Felis catus	CSF1R	VGNC	VGNC:61215
Canis familiaris	CSF1R	VGNC	VGNC:39653
Others	CSF1R	NCBI