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Art. -Nr.: HY-158363

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CSF1R-IN-25

CSF1R-IN-25 (compound 36) is an orally effective CSF1R inhibitor. CSF1R-IN-25 can be used to study cancer, inflammation, and neurodegeneration.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2070864-23-0
Formel: C₂₇H₂₇N₅O₃
Molecular Weight:469.53

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CSF1R-IN-25 Chemical Structure

CAS. Nr.: 2070864-23-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CSF1R-IN-25 (compound 36) is an orally effective CSF1R inhibitor. CSF1R-IN-25 can be used to study cancer, inflammation, and neurodegeneration^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	IC₅₀	5 nM Compound: 36	Inhibition of recombinant mouse M-CSF induced cell proliferation in mouse BMDM cells incubated for 1 day by 3H-radioligand based scintillation counter Inhibition of recombinant mouse M-CSF induced cell proliferation in mouse BMDM cells incubated for 1 day by 3H-radioligand based scintillation counter	[PMID: 38746878]

Chemical Information

CAS. Nr. 2070864-23-0
Molecular Weight 469.53
Formel C₂₇H₂₇N₅O₃
SMILES

COC1=CC=C(COC2=CC=C(C=C2OC)CN3C=NC4=CC(C#CC5CNCC5)=CN=C43)C=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kane JL Jr, et al. Identification of Selective Imidazopyridine CSF1R Inhibitors. ACS Med Chem Lett. 2024 Apr 30;15(5):722-730. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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