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Cat. No.: HY-161084

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CSF1R-IN-18

CSF1R-IN-18 (Compdound 16t), para-aniline derivative, is a colony-stimulating factor 1 receptor (CSF1R) inhibitor. CSF1R-IN-18 can be used for the research of cancers, CNS-diseases and bone diseases.

For research use only. We do not sell to patients.

CAS No.: 3034869-67-2
Formula: C₁₉H₂₃N₅O
Molecular Weight:337.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CSF1R-IN-18 Chemical Structure

CAS No.: 3034869-67-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CSF1R-IN-18 (Compdound 16t), para-aniline derivative, is a colony-stimulating factor 1 receptor (CSF1R) inhibitor. CSF1R-IN-18 can be used for the research of cancers, CNS-diseases and bone diseases^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	1.2 μM Compound: 16t	Cytotoxicity against CSF1R-dependent mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay Cytotoxicity against CSF1R-dependent mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay	[PMID: 38141285]
BaF3	IC₅₀	9.9 μM Compound: 16t	Cytotoxicity against IL-3-dependent mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay Cytotoxicity against IL-3-dependent mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay	[PMID: 38141285]

Chemical Information

CAS No. 3034869-67-2
Molecular Weight 337.42
Formula C₁₉H₂₃N₅O
SMILES

CN(CC1CCOCC1)C2=C3C(NC(C4=CC=C(N)C=C4)=C3)=NC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bjørnstad F, et al. Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland. Eur J Med Chem. 2023 Dec 17;265:116053. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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