2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. Emactuzumab

Emactuzumab  (Synonyms: RG 7155; RO 5509554)

Cat. No.: HY-P99245 Purity: 97.60%
COA

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Emactuzumab(RG 7155) is a specific monoclonal antibody that inhibits colonystimulating factor 1 receptor (CSF1R) activation. Emactuzumab has high affinity for CSF-1R with Ki value of 0.2 nM to blocks CSF-1R dimerization. Emactuzumab can be used for the research of several diseases, such as diffuse-type tenosynovial giant cell tumour (dt-GCT) .

For research use only. We do not sell to patients.

Emactuzumab Chemical Structure

Emactuzumab Chemical Structure

CAS No. : 1448221-67-7

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Emactuzumab Related Antibodies

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Description

Emactuzumab(RG 7155) is a specific monoclonal antibody that inhibits colonystimulating factor 1 receptor (CSF1R) activation. Emactuzumab has high affinity for CSF-1R with Ki value of 0.2 nM to blocks CSF-1R dimerization. Emactuzumab can be used for the research of several diseases, such as diffuse-type tenosynovial giant cell tumour (dt-GCT) [1][2].

IC50 & Target

IC50: 0.2 nM (CSF-1R)[2]
In Vitro

Emactuzumab (RG 7155) binds to human and cynomolgus CSF-1R with high affinity (Kd = 0.2 nM) to blocks CSF-1R dimerization[2].
RG7155 (0-10 μg/mL, 7 days) potently inhibited the viability of CSF-1-differentiated macrophages with an IC50 of 0.3 nM by inducing cell death[2].
RG7155 (30 μg/mL, 6 days) induces cell death of in vitro-differentiated human M2-like macrophages[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emactuzumab Related Antibodies

Cell Viability Assay[2]

Cell Line: CSF-1 and/or GM-CSF Macrophages
Concentration: 0-10 μg/mL
Incubation Time: 7 days
Result: Resulted cell death of CSF-1-differentiated macrophages.
In Vivo

Emactuzumab(RG 7155) (i.v.; 0.1、1、10、30 and 100 mg/kg; once) increases CSF-1 concentration in nonhuman primates’ peripheral blood[2].
RG7155 (i.v.; 0, 30, and 100 mg/kg; once weekly; for 2 weeks) depletes CSF-1R+CD163+ macrophages in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: cynomolgus monkeys Macaca fascicularis[2]
Dosage: 0.1, 1, 10, 30 and 100 mg/kg (male cynomolgus monkeys)
0, 30, and 100 mg/kg (male and female cynomolgus)
Administration: i.v., once (male cynomolgus monkeys)
i.v., once weekly, for 2 weeks(male and female cynomolgus)
Result: Increased CSF-1 concentration in serum.
Efficiently reduced CSF-1R and CD68+163+ macrophages in the liver (Kupffer cells) and colon of cynomologus monkeys.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Emactuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 97.60%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Emactuzumab Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emactuzumab1448221-67-7RG 7155 RO 5509554RG7155RG-7155RO5509554RO 5509554RO-5509554c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1Rdiffuse-type tenosynovial giant cell tumour (dt-GCT)colonystimulating factor 1 (CSF1)CSF1 receptor (CSFIR)tumor-associated macrophages (TAMs)macrophagesIgG1antibodycancerInhibitorinhibitorinhibit

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