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Cat. No.: HY-158148

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CSF1R-IN-23

CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulating factor-1 receptor (CSF1R), with IC₅₀ of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable.

For research use only. We do not sell to patients.

CAS No.: 2935480-17-2
Formula: C₂₇H₃₇N₃O₂
Molecular Weight:435.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CSF1R-IN-23 Chemical Structure

CAS No.: 2935480-17-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

CSF1R-IN-23 (0-10 μM, 30 min) inhibits autophosphorylation of CSF1R in cells RAW264.7 and microglial cells EOC20, without significant cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

EOC20 and RAW264.7
Concentration:

0-10 μM
Incubation Time:

30 min
Result:

Inhibited phosphorylation of CSF1R.

In Vivo

CSF1R-IN-23 (0.5 mg/kg, i.p. every two days for 4 doses) ameliorates the Lipopolysaccharide (HY-D1056)-induced neuroinflammation in C57BL/6J mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS-induced neuroinflammation in C57BL/6J mice model^[1]
Dosage:

0.5 mg/kg
Administration:

i.p., every two days for 4 doses
Result:

Eliminated the 76% microglias in hippocampus, cortex, and thalamus.

Chemical Information

CAS No. 2935480-17-2
Molecular Weight 435.60
Formula C₂₇H₃₇N₃O₂
SMILES

CC1(NC(C)(CC(C1)C2=CC(C3=CCC(CC3)C)=C(C=C2)NC(C4=NOC(C)=C4)=O)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Baek J, et al., Targeting the CSF-1/CSF-1R Axis: Exploring the Potential of CSF1R Inhibitors in Neurodegenerative Diseases. J Med Chem. 2024 Apr 11;67(7):5699-5720. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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