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Cat. No.: HY-13839

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PLX647-OMe

PLX647-OMe is a 5-methoxy analog of PLX647 (HY-13838) and a FMS (CSF1R) inhibitor derived from a 7-azaindole scaffold with an IC₅₀ of 62 nM. PLX647-OMe can be used in research related to FMS-mediated diseases, such as cancer.

For research use only. We do not sell to patients.

CAS No.: 923562-22-5
Formula: C₂₂H₁₉F₃N₄O
Molecular Weight:412.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PLX647-OMe Chemical Structure

CAS No.: 923562-22-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

PLX647-OMe is an FMS (CSF1R) inhibitor with an IC₅₀ of 62 nM; it binds the DFG-out autoinhibitory conformation of FMS and forms a hydrogen bond with the backbone NH of the DFG aspartate^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 923562-22-5
Molecular Weight 412.42
Formula C₂₂H₁₉F₃N₄O
SMILES

FC(F)(F)C1=CC=C(C=C1)CNC2=NC=C(C=C2)CC3=CNC=4N=CC(OC)=CC43
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang C, et al. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 2013 Apr 02;110(14):5689-94. [Content Brief]

[2]. Zhang H, et al. Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling. Molecules (Basel, Switzerland). 2023 Jan 17;28(3):943.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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