923562-22-5
923562-22-5
Chemical Structure
PLX647-OMe
- CAS No.: 923562-22-5
- Formula:C22H19F3N4O
- Molecular Weight:412.42
IUPAC Name: 5-((5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-(4-(trifluoromethyl)benzyl)pyridin-2-amine
InChIKey: WLYQGNIWNGFGPH-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=CC=C(C=C1)CNC2=NC=C(C=C2)CC3=CNC=4N=CC(OC)=CC43
Biological Activity: PLX647-OMe is a 5-methoxy analog of PLX647 (HY-13838) and a FMS (CSF1R) inhibitor derived from a 7-azaindole scaffold with an IC50 of 62 nM. PLX647-OMe can be used in research related to FMS-mediated diseases, such as cancer[1][2].
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PLX647-OMe | PLX647-OMe is a 5-methoxy analog of PLX647 (HY-13838) and a FMS (CSF1R) inhibitor derived from a 7-azaindole scaffold with an IC50 of 62 nM. PLX647-OMe can be used in research related to FMS-mediated diseases, such as cancer. | |||||||||||||||||||||
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References
- [1]. Zhang C, et al. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 2013 Apr 02;110(14):5689-94. [Content Brief]
- [2]. Zhang H, et al. Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling. Molecules (Basel, Switzerland). 2023 Jan 17;28(3):943.
