PPARγ-IN-3
PPARγ-IN-3 (compound 9ga) is a potent and orally active PPARγ inhibitor. PPARγ-IN-3 reduces triglyceride (TG) accumulation with low cytotoxicity. PPARγ-IN-3 preventes the excessive growth of body weight and lessened fat mass as well as liver mass, decreases lipid accumulation in the liver and blood. PPARγ-IN-3 has the potential for the research of diet-induced obesity.
For research use only. We do not sell to patients.
- Formula: C23H28FN7O3
- Molecular Weight:469.51
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PPARγ |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | EC50 |
0.07 μM
Compound: 9ga
|
Lipid-lowering activity in differentiated mouse 3T3-L1 cells assessed as reduction in lipid droplet accumulation incubated in differentiation medium for 9 days by Oil Red O staining based analysis
Lipid-lowering activity in differentiated mouse 3T3-L1 cells assessed as reduction in lipid droplet accumulation incubated in differentiation medium for 9 days by Oil Red O staining based analysis
|
[PMID: 39163779] |
| 3T3-L1 | IC50 |
23.89 μM
Compound: 9ga
|
Cytotoxicity against undifferentiated mouse 3T3-L1 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
Cytotoxicity against undifferentiated mouse 3T3-L1 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
|
[PMID: 39163779] |
Chemical Information
-
Molecular Weight 469.51
-
Formula C23H28FN7O3
-
SMILES
COC1=CC=C(NC(C2=NC(C)=C(F)C(NCCN3CCCC3)=N2)=C4/C=N/NC(OC)=O)C4=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz