PPARγ-IN-3
PPARγ-IN-3 (compound 9ga) is a potent and orally active PPARγ inhibitor. PPARγ-IN-3 reduces triglyceride (TG) accumulation with low cytotoxicity. PPARγ-IN-3 preventes the excessive growth of body weight and lessened fat mass as well as liver mass, decreases lipid accumulation in the liver and blood. PPARγ-IN-3 has the potential for the research of diet-induced obesity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C23H28FN7O3
- Peso molecular:469.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
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PPARγ |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | EC50 |
0.07 μM
Compound: 9ga
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Lipid-lowering activity in differentiated mouse 3T3-L1 cells assessed as reduction in lipid droplet accumulation incubated in differentiation medium for 9 days by Oil Red O staining based analysis
Lipid-lowering activity in differentiated mouse 3T3-L1 cells assessed as reduction in lipid droplet accumulation incubated in differentiation medium for 9 days by Oil Red O staining based analysis
|
[PMID: 39163779] |
| 3T3-L1 | IC50 |
23.89 μM
Compound: 9ga
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Cytotoxicity against undifferentiated mouse 3T3-L1 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
Cytotoxicity against undifferentiated mouse 3T3-L1 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
|
[PMID: 39163779] |
Chemical Information
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Peso molecular 469.51
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Fòrmula C23H28FN7O3
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SMILES
COC1=CC=C(NC(C2=NC(C)=C(F)C(NCCN3CCCC3)=N2)=C4/C=N/NC(OC)=O)C4=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)