PPARγ-IN-3
PPARγ-IN-3 (compound 9ga) is a potent and orally active PPARγ inhibitor. PPARγ-IN-3 reduces triglyceride (TG) accumulation with low cytotoxicity. PPARγ-IN-3 preventes the excessive growth of body weight and lessened fat mass as well as liver mass, decreases lipid accumulation in the liver and blood. PPARγ-IN-3 has the potential for the research of diet-induced obesity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C23H28FN7O3
- 分子量:469.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
IC50 & Target
[1]|
PPARγ |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | EC50 |
0.07 μM
Compound: 9ga
|
Lipid-lowering activity in differentiated mouse 3T3-L1 cells assessed as reduction in lipid droplet accumulation incubated in differentiation medium for 9 days by Oil Red O staining based analysis
Lipid-lowering activity in differentiated mouse 3T3-L1 cells assessed as reduction in lipid droplet accumulation incubated in differentiation medium for 9 days by Oil Red O staining based analysis
|
[PMID: 39163779] |
| 3T3-L1 | IC50 |
23.89 μM
Compound: 9ga
|
Cytotoxicity against undifferentiated mouse 3T3-L1 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
Cytotoxicity against undifferentiated mouse 3T3-L1 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
|
[PMID: 39163779] |
化学情報
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分子量 469.51
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分子式 C23H28FN7O3
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SMILES
COC1=CC=C(NC(C2=NC(C)=C(F)C(NCCN3CCCC3)=N2)=C4/C=N/NC(OC)=O)C4=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)