TMC1 Antibody (YA6801)
(Synonyms: Transmembrane channel-like protein 1 1 publication Alternative names Transmembrane cochlear-expressed protein 1 Gene names Name TMC1)
Based on 1 Customer Validation
TMC1 Antibody (YA6801) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TMC1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:2000 | 1:2000 |
Product Details
TMC1 Antibody (YA6801) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TMC1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 88 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 88 kDa
Recombinant protein within human TMC1 aa 1-150.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TMC1 is a Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located. TMC1 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cells transduction current
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Detected in fetal cochlea, and at low levels in placenta and testis -
Isoforms & Post-Translational Modification
Q8TDI8: 760 amino acids, molecular weight 87768 Da.
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Subunit
Forms the MET channel complosed of TMC dimer (TMC1 or TMC2), TMIE, TOMT, CIB (CIB2 or CIB3), LHFPL5 and PDH15 (PubMed:30138589, PubMed:34089643)
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SwissProt ID
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Synonyms
Transmembrane channel-like protein 1 1 publication Alternative names Transmembrane cochlear-expressed protein 1 Gene names Name TMC1
Documentation
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