TMEM100 Antibody (YA8588)(PBS only)
(Synonyms: FLJ10970; FLJ37856)TMEM100 Antibody (YA8588) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TMEM100.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:50-250 | 1:100-250 |
Product Details
TMEM100 Antibody (YA8588) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TMEM100.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 14.4 kDa
Full length human recombinant protein of human TMEM100 produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TMEM100 plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex
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Subcellular Localization
Cell membrane,Membrane,Perikaryon,Cytoplasm, perinuclear region,Endoplasmic reticulum
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Expression
Tissue_Specificity: Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system. Expressed in umbilical artery endothelial cells (at protein level)
Induction: Up-regulated by GDF2/BMP9 and BMP10 (at protein level) -
Isoforms & Post-Translational Modification
Q9NV29: 134 amino acids, molecular weight 14386 Da.
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Subunit
Interacts (via C-terminus) with TRPA1 and TRPV1 (By similarity)
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SwissProt ID
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Synonyms
FLJ10970; FLJ37856
Documentation
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