TMEM100 Antibody (YA8588)(PBS only)

Cat. No.: HY-P88904A: Data Sheet User Guide for Antibodies
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TMEM100 Antibody (YA8588) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TMEM100.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

TMEM100 Antibody (YA8588) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TMEM100.

Host

Mouse

Molecular Weight

Predicted band size: 14.4 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9NV29

Immunogen

Full length human recombinant protein of human TMEM100 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-250
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex

Subcellular Localization：Cell membrane,Membrane,Perikaryon,Cytoplasm, perinuclear region,Endoplasmic reticulum

Expression：
Tissue_Specificity: Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system. Expressed in umbilical artery endothelial cells (at protein level)
Induction: Up-regulated by GDF2/BMP9 and BMP10 (at protein level)

Isoforms & Post-Translational Modification：Q9NV29: 134 amino acids, molecular weight 14386 Da.

Subunit：Interacts (via C-terminus) with TRPA1 and TRPV1 (By similarity)

Synonyms

FLJ10970; FLJ37856

Documentation

User Guide for Antibodies (1077 KB)