2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. TRIM38 Antibody (YA8605)

TRIM38 Antibody (YA8605)

製品番号: HY-P88921
User Guide for Antibodies Technical Support

TRIM38 Antibody (YA8605) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIM38.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

TRIM38 Antibody (YA8605) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIM38.
Host

Mouse
Clonality

Monoclonal
分子量

Predicted band size: 53.2 kDa
Species Reactivity
Human, Dog, Rat, Monkey, Mouse
SwissProt ID
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-265 of human TRIM38 produced in E.coli.
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:150-500
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:100-250
Sensitivity Endogenous 純度 Affinity purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG1  
Appearance

Liquid
Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470). Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549)
Subcellular Localization：Cytoplasm
Expression：
Tissue_Specificity: Ubiquitous
Isoforms & Post-Translational Modification：O00635: 465 amino acids, molecular weight 53416 Da.
Subunit：Interacts (via B30
Synonyms
RNF15; RORET
ドキュメンテーション
User Guide for Antibodies (1077 KB)

TRIM38 Antibody (YA8605) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
TRIM38 Antibody (YA8605)
製品番号:
HY-P88921
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