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TRIM38 Antibody (YA8605)

(Synonyms: RNF15; RORET)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

TRIM38 Antibody (YA8605) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIM38.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P, ICC/IF

  • Reactivity :

    Human, Dog, Rat, Monkey, Mouse

  • Formulation:

    Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for TRIM38 Antibody (YA8605)
  • TRIM38 Antibody (YA8605) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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1 Publications Citing Use of MCE TRIM38 Antibody (YA8605) (1)
IF
  • IF

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:150-500 1:100-250

Product Details

Description

TRIM38 Antibody (YA8605) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIM38.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Dog, Rat, Monkey, Mouse
  • Calculated Molecular Weight Predicted band size: 53.2 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-265 of human TRIM38 produced in E.coli.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TRIM38 is an E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity. Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus. Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters[1][2].

  • Subcellular Localization

    Cytoplasm

  • Expression


    Tissue_Specificity: Ubiquitous

  • Isoforms & Post-Translational Modification

    O00635: 465 amino acids, molecular weight 53416 Da.

  • Subunit

    Interacts (via B30

  • SwissProt ID

    O00635

  • Synonyms

    RNF15; RORET

TRIM38 Antibody (YA8605) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    TRIM38 Antibody (YA8605) purchased from MedChemExpress. Usage Cited in: Drug Dev Res. 2026 Aug;87(5):e70340.

    Customer Validation
     Immunofluorescence staining showed the co-localization of TRIM38 and IRAK1 proteins in the cytoplasm of H9c2 cells. Primary antibodies, including mouse anti-TRIM38 antibody (TRIM38 Antibody (YA8605)) (1:100, HY-P88921) and rabbit anti-IRAK1 antibody (1:200), were dropped onto H9c2 cells. After 12 h of incubation at 4°C, AF488-conjugated Goat Anti-Mouse IgG H&L (1:200, HY-P8005) or AF555-conjugated Goat Anti-Rabbit IgG H&L (1:200, HY-P81005) secondary antibodies were dropped onto H9c2 cells for 2 h of incubation in the dark.

  • TRIM38 Antibody (YA8605) Product Image
    1/16
  • Experimental Validation Results for TRIM38 Antibody (YA8605)
  • TRIM38 Antibody (YA8605) Product Image

  • TRIM38 Antibody (YA8605) purchased from MedChemExpress. Usage Cited in: Drug Dev Res. 2026 Aug;87(5):e70340.

    Immunofluorescence staining showed the co-localization of TRIM38 and IRAK1 proteins in the cytoplasm of H9c2 cells. Primary antibodies, including mouse anti-TRIM38 antibody (TRIM38 Antibody (YA8605)) (1:100, HY-P88921) and rabbit anti-IRAK1 antibody (1:200), were dropped onto H9c2 cells. After 12 h of incubation at 4°C, AF488-conjugated Goat Anti-Mouse IgG H&L (1:200, HY-P8005) or AF555-conjugated Goat Anti-Rabbit IgG H&L (1:200, HY-P81005) secondary antibodies were dropped onto H9c2 cells for 2 h of incubation in the dark.