WWOX Antibody (YA3315)(PBS only)

Cat. No.: HY-P83570A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

WWOX Antibody (YA3315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WWOX.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

WWOX Antibody (YA3315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WWOX.

Host

Rabbit

Molecular Weight

Predicted band size: 47 kDa;

Observed band size: 47 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

Q9NZC7

Gene ID

51741 [NCBI]

Immunogen

Recombinant protein of human WWOX

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	200-1:1000
FC FC: Flow Cytometry	1:200-1:500
IP IP: Immunoprecipitation	1:20-1:50

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm

Subcellular Localization：Cytoplasm; Nucleus; Mitochondrion; Golgi apparatus; Lysosome

Expression：
Tissue_specificity:Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines

Isoforms & Post-Translational Modification：Q9NZC7 has 7 isomers: Q9NZC7-1: 46677 Da (predicted); Q9NZC7-2: 41128 Da (predicted); Q9NZC7-3: 21559 Da (predicted); Q9NZC7-4: 4150 Da (predicted); Q9NZC7-5: 26148 Da (predicted); Q9NZC7-6: 35042 Da (predicted); Q9NZC7-7: 23868 Da (predicted).
Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation;Ubiquitinated when phosphorylated by TNK2, leading to its degradation

Subunit：Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207. Interacts (via WW domain) with VOPP1 (PubMed:30285739)

Research Field

Cell Biology

Synonyms

FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E

Documentation

User Guide for Antibodies (1077 KB)