Antimicrobial agent-52
Antimicrobial agent-52 is a broad-spectrum Bactericide. Antimicrobial agent-52 exerts rapid bactericidal effects against Gram-positive and Gram-negative pathogenic bacteria. Antimicrobial agent-52 exhibits activity against Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Escherichia coli. Antimicrobial agent-52 can be used in the research of bacterial infections.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C26H20N2O6
- Masse moléculaire:456.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Antimicrobial agent-52 (24 h) exhibits bactericidal activity in vitro against Staphylococcus aureus (MBC = 1.56 μM), Klebsiella pneumoniae (MBC = 0.19 μM), Acinetobacter baumannii (MBC = 1.56 μM), and Escherichia coli (MBC = 0.04 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7, J774A.1, HEK293
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Concentration:6.25-200 μM
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Incubation Time:20 h (with compound); 4 h (with MTT)
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Result:Induced concentration-dependent cytotoxicity, with cell viability values of ~32%, ~40%, ~47%, ~55%, ~69%, and ~80% for RAW 264.7 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Induced concentration-dependent cytotoxicity, with cell viability values of ~32%, ~40%, ~47%, ~55%, ~69%, and ~80% for J774A.1 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Induced concentration-dependent cytotoxicity, with cell viability values of ~44%, ~70%, ~87%, ~88%, ~93%, and ~96% for HEK293 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Calculated CC50 values were 42.27 μM for RAW 264.7, 49.58 μM for J774A.1, and 200 μM for HEK293.
Achieved Selectivity Index (SI) values ranging from 48.03 to 2113.5 for RAW 264.7, 56 to 2479 for J774A.1, and 227.27 to 10,000 for HEK293 against the four bacterial strains.
Chemical Information
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Masse moléculaire 456.45
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Formule C26H20N2O6
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SMILES
O=C1C=C(C2=CC=CC=C2)OC3=C1C(OCC4=CC(C5=NC=CC=C5)=NO4)=C(OC)C(OC)=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimicrobial agent-52 Related Classifications
HY-184904 Related Classifications
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Keywords
- Antimicrobial agent-52
- Antimicrobial agent52
- Antimicrobial agent 52
- Bacterial
- outer membrane protein A
- Gram-positive bacterial pathogens
- Gram-negative bacterial pathogens
- Staphylococcus aureus
- extended-spectrum β-lactamase
- Klebsiella pneumoniae
- Escherichia coli
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate ligase
- clumping factor A
- Acinetobacter baumannii
- Inhibitor
- inhibitor
- inhibit