Antimicrobial agent-52
Antimicrobial agent-52 is a broad-spectrum Bactericide. Antimicrobial agent-52 exerts rapid bactericidal effects against Gram-positive and Gram-negative pathogenic bacteria. Antimicrobial agent-52 exhibits activity against Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Escherichia coli. Antimicrobial agent-52 can be used in the research of bacterial infections.
For research use only. We do not sell to patients.
- Formula: C26H20N2O6
- Molecular Weight:456.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antimicrobial agent-52 (Compound 4p) (0.01-25 μM; 24 h) potently inhibits the growth of Staphylococcus aureus (MIC = 0.88 μM), Klebsiella pneumoniae (MIC = 0.15 μM), Acinetobacter baumannii (MIC = 0.76 μM), and Escherichia coli (MIC = 0.02 μM) in vitro[1].
Antimicrobial agent-52 (24 h) exhibits bactericidal activity in vitro against Staphylococcus aureus (MBC = 1.56 μM), Klebsiella pneumoniae (MBC = 0.19 μM), Acinetobacter baumannii (MBC = 1.56 μM), and Escherichia coli (MBC = 0.04 μM)[1].
Antimicrobial agent-52 (6.25-200 μM; 24 h) exhibits a CC50 value of 42.27 μM in RAW 264.7 cells, 49.58 μM in J774A.1 cells, and 200 μM in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7, J774A.1, HEK293
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Concentration:6.25-200 μM
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Incubation Time:20 h (with compound); 4 h (with MTT)
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Result:Induced concentration-dependent cytotoxicity, with cell viability values of ~32%, ~40%, ~47%, ~55%, ~69%, and ~80% for RAW 264.7 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Induced concentration-dependent cytotoxicity, with cell viability values of ~32%, ~40%, ~47%, ~55%, ~69%, and ~80% for J774A.1 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Induced concentration-dependent cytotoxicity, with cell viability values of ~44%, ~70%, ~87%, ~88%, ~93%, and ~96% for HEK293 at 200, 100, 50, 25, 12.5, and 6.25 μM, respectively.
Calculated CC50 values were 42.27 μM for RAW 264.7, 49.58 μM for J774A.1, and 200 μM for HEK293.
Achieved Selectivity Index (SI) values ranging from 48.03 to 2113.5 for RAW 264.7, 56 to 2479 for J774A.1, and 227.27 to 10,000 for HEK293 against the four bacterial strains.
Chemical Information
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Molecular Weight 456.45
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Formula C26H20N2O6
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SMILES
O=C1C=C(C2=CC=CC=C2)OC3=C1C(OCC4=CC(C5=NC=CC=C5)=NO4)=C(OC)C(OC)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimicrobial agent-52 Related Classifications
HY-184904 Related Classifications
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- Antimicrobial agent-52
- Antimicrobial agent52
- Antimicrobial agent 52
- Bacterial
- outer membrane protein A
- Gram-positive bacterial pathogens
- Gram-negative bacterial pathogens
- Staphylococcus aureus
- extended-spectrum β-lactamase
- Klebsiella pneumoniae
- Escherichia coli
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate ligase
- clumping factor A
- Acinetobacter baumannii
- Inhibitor
- inhibitor
- inhibit