Antitubercular agent-58
Antitubercular agent-58 is an antitubercular agent with an IC50 of 51 nM against Mycobacterium tuberculosis H37Rv. Antitubercular agent-58 can be used for the research of tuberculosis.
For research use only. We do not sell to patients.
- Formula: C22H22FN3O3
- Molecular Weight:395.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Antitubercular agent-58 (Compound 20j) potently inhibits the growth of Mycobacterium tuberculosis H37Rv whole cells with an IC50 of 51 nM[1].
Antitubercular agent-58 shows high metabolic clearance in rat hepatocytes and moderate metabolic clearance in human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 395.43
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Formula C22H22FN3O3
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SMILES
O=C1C(C(C2=CC=C(N3C[C@@H](C)O[C@@H](C)C3)C=C2)=C1NCC4=NC(F)=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitubercular agent-58 Related Classifications
HY-183550 Related Classifications
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