β-catenin-IN-10
β-catenin-IN-10 is a β-catenin:TCF4 interaction inhibitor with an IC50 of 5.44 μM. β-catenin-IN-10 inhibits the Wnt and AR signaling pathways with IC50 values of 0.105 μM and 1.02 μM, respectively. β-catenin-IN-10 suppresses the proliferation of castration-resistant prostate cancer cells. β-catenin-IN-10 is applicable to research related to prostate cancer.
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- Formel: C74H97N11O17
- Molecular Weight:1412.63
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
β-catenin-IN-10 (10 μM; 24 h) regulates the expression of Wnt and AR target genes in LNCaP-abl and LNCaP-95 prostate cancer cells, reduces oncogenic target transcripts, and upregulates E-cadherin[1].
β-catenin-IN-10 (0.195-0.782 μM; 5 d) potently inhibits the proliferation of castration-resistant prostate cancer cells LNCaP-abl and LNCaP-95 in 2D culture systems, with IC50 values of 0.195 μM and 0.782 μM for the two cell lines, respectively, but exerts no effect on non-prostate cancer cells independent of Wnt signaling[1].
β-catenin-IN-10 (0.694-1.34 μM; 17-22 d) inhibits the proliferation of LNCaP-abl prostate cancer spheroids in a 3D culture system; when the compound is added at the time of seeding, its IC50 is 0.694 μM, whereas when added to pre-formed spheroids, the IC50 is 1.34 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LNCaP-abl and LNCaP-95 castration-resistant prostate cancer cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Decreased mRNA levels of Wnt target genes (AR, cMYC, Cyclin D1), AR target genes (PSA, FKBP5), and the constitutively active AR splice variant AR-V7; increased mRNA levels of E-cadherin, a gene repressed by Wnt signaling.
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Cell Line:LNCaP-abl, LNCaP-95, U2OS, and A549 cells
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Concentration:0.195 μM IC50 (LNCaP-abl); 0.782 μM IC50 (LNCaP-95); 0.001 to 100 μM (dose range)
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Incubation Time:5 days
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Result:Inhibited proliferation of LNCaP-abl cells with an IC50 of 0.195 μM and LNCaP-95 cells with an IC50 of 0.782 μM; had no effect on proliferation of Wnt-independent U2OS (osteosarcoma) and A549 (lung adenocarcinoma) cells.
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Cell Line:LNCaP-abl prostate cancer cells
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Concentration:0.694 μM IC50 (Day 0 addition); 1.34 μM IC50 (Day 5 addition); 0.001 to 100 μM (dose range); ≥1 μM (spheroid formation inhibition/growth stall)
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Incubation Time:22 days total (Day 0 addition, media changes every 3-4 days); 17 days total (Day 5 addition, media changes every 3-4 days)
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Result:When added on Day 0, inhibited spheroid proliferation with an IC50 of 0.694 μM; when added to pre-formed spheroids on Day 5, inhibited proliferation with an IC50 of 1.34 μM.
Concentrations ≥1 μM prevented spheroid formation or stalled growth of pre-formed spheroids.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild-type (embryos)[1]
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Dosage:10 μM
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Administration:immersion; single dose at 5.5 hours post-fertilization
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Result:Rescued eye development in 100% of embryos (8/8 embryos in each of 3 independent experiments).
Chemical Information
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Molecular Weight 1412.63
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Formel C74H97N11O17
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
β-catenin-IN-10 Related Classifications
HY-P11660 Related Classifications
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