D1R antagonist 2
D1R antagonist 2 (Compound 13a) is a BBB-penetrable D1R antagonist with IC50s of 35.6 and 70 nM for cAMP-based D1R and β-arrestin-based D1R, respectively. D1R antagonist 2 effectively antagonizes D1R-mediated cAMP and β-arrestin recruitment. D1R antagonist 2 can be used for neurodegenerative and neuropsychiatric diseases such as schizophrenia, Parkinson’s disease and Alzheimer’s disease research.
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- Formel: C21H22BrF2NO4
- Molecular Weight:470.30
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
D1 Receptor 35.6 ( cAM nM (IC50) |
D1 Receptor 70 (β-arre nM (IC50) |
Chemical Information
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Molecular Weight 470.30
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Formel C21H22BrF2NO4
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SMILES
FC(F)COC1=C(O)C=C([C@H](CC2=C(Br)C=C(O)C(OCC)=C2C3)N3CC4)C4=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
D1R antagonist 2 Related Classifications
HY-178103 Related Classifications
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