Daxdilimab
Based on 1 Customer Validation
Daxdilimab (MEDI7734; VIB7734) is a monoclonal antibody targeting immunoglobulin-like transcript 7 (ILT7) that depletes plasmacytoid dendritic cells and reduces IFN1 production by binding to the plasmacytoid dendritic cell-specific surface molecule ILT7 and recruiting effector natural killer cells. Daxdilimab (MEDI7734; VIB7734) can be used for research on systemic lupus erythematosus, systemic sclerosis, and polymyositis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 97.82%
- CAS. Nr.: 2245966-28-1
- Molecular Weight:144.38 kDa
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
Isotype
Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
ILT7 |
IFN1 |
In Vitro
Daxdilimab (MEDI7734; VIB7734) (10-4 to 103 relative value; IC50-corrected) has an IC50 of 8.4 ng/mL and achieves 34% maximal IFNGS inhibition at typical parameter values[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Human IgG1 lambda2
Anwendung
ELISA, FACS, Functional assay
Verified Bioactivity
-
Immobilized LILRA4/ILT-7/CD85g Protein, Human (HEK293, His, HY-P77441) can bind Daxdilimab. The EC50 for this effect is 641.3 ng/mL.
Chemical Information
-
CAS. Nr. 2245966-28-1
-
Appearance Liquid
-
Molecular Weight 144.38 kDa
-
Color Colorless to light yellow
-
SMILES
[Daxdilimab]
-
Synonyms
MEDI7734; VIB7734
-
Versand
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
-
Monocyte-derived dendritic cell differentiation
Human monocyte-derived dendritic cells are generated by isolating PBMC-derived monocytes and culturing them with GM-CSF plus IL-4, which produces cells with dendritic-cell antigen-presenting properties, reduced monocyte phenotype, and increased dendritic-cell functional readouts such as antigen uptake, allogeneic T-cell stimulation, and expression of markers including HLA-DR, CD80, CD86, CD83, CD1a, or CD209 depending on protocol and maturation state. The main readout is phenotypic and functional differentiation: immature MoDCs are commonly evaluated by loss or reduction of CD14 with acquisition of dendritic-cell markers and antigen uptake capacity, whereas mature MoDCs are evaluated by increased CD83, CD80, CD86, HLA-DR, and T-cell stimulatory function after exposure to maturation stimuli such as TNF-α or a cytokine/PGE2 cocktail.
Reinheit & Dokumentation
-
Data Sheet (267 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Daxdilimab Related Classifications
HY-P99226 Related Classifications
Powered by Bioz
Keywords
- Daxdilimab
- 2245966-28-1
- MEDI7734
- VIB7734
- MEDI 7734
- MEDI-7734
- VIB7734
- VIB 7734
- VIB-7734
- Human leukocyte immunoglobulin (Ig)-like receptors (LILR)
- IFNAR
- immunoglobulin-like transcript 7
- IFN1
- type I interferon
- dermatomyositis
- plasmacytoid dendritic cells
- cutaneous lupus erythematosus
- systemic sclerosis
- systemic lupus erythematosus
- natural killer cells
- ILT7
- Inhibitor
- inhibitor
- inhibit