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Art. -Nr.: HY-114503A

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(E/Z)-NSAH

Name: (E/Z)-NSAH
Brand: MedChemExpress
SKU: HY-114503A
Price: 89.00 USD
Availability: InStock
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(E/Z)-NSAH is an isoform of NSAH (HY-114503), which is reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC₅₀ of 32 μM and cell-based IC₅₀ of ~250 nM, respectively.

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CAS. Nr.: 54009-54-0
Formel: C₁₈H₁₄N₂O₃
Molecular Weight:306.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

(E/Z)-NSAH Chemical Structure

CAS. Nr.: 54009-54-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	225 nM Compound: E-3a	Growth inhibition of human HCT116 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay Growth inhibition of human HCT116 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]
MDA-MB-231	IC₅₀	0.347 μM Compound: E-3a	Growth inhibition of human MDA-MB-231 cells treated with 4 pmol RRM1 siRNA after 5 days by Hoechst 33258 dye based fluorescence assay Growth inhibition of human MDA-MB-231 cells treated with 4 pmol RRM1 siRNA after 5 days by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]
MDA-MB-231	IC₅₀	1.43 μM Compound: E-3a	Growth inhibition of human MDA-MB-231 cells treated with 2 pmol RRM1 siRNA at 0.1 to 10 uM after 5 days by Hoechst 33258 dye based fluorescence assay Growth inhibition of human MDA-MB-231 cells treated with 2 pmol RRM1 siRNA at 0.1 to 10 uM after 5 days by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]
MDA-MB-231	IC₅₀	1.49 μM Compound: E-3a	Growth inhibition of human MDA-MB-231 cells after 5 days by Hoechst 33258 dye based fluorescence assay Growth inhibition of human MDA-MB-231 cells after 5 days by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]
MDA-MB-231	IC₅₀	1.94 μM Compound: E-3a	Growth inhibition of human MDA-MB-231 cells treated with 4 pmol scrambled siRNA after 5 days by Hoechst 33258 dye based fluorescence assay Growth inhibition of human MDA-MB-231 cells treated with 4 pmol scrambled siRNA after 5 days by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]
MDA-MB-231	IC₅₀	300 nM Compound: E-3a	Growth inhibition of human MDA-MB-231 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay Growth inhibition of human MDA-MB-231 cells after 72 hrs by Hoechst 33258 dye based fluorescence assay	[PMID: 29253340]

Chemical Information

CAS. Nr. 54009-54-0
Molecular Weight 306.32
Formel C₁₈H₁₄N₂O₃
SMILES

O=C(C1=CC=CC=C1O)N/N=C/C2=C3C=CC=CC3=CC=C2O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8241-8246. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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