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Art. -Nr.: HY-14767

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Fasobegron

Fasobegron is a β₃-adrenergic receptor agonist with a human EC₅₀ of 4.8 nM. Fasobegron shows an EC₅₀ of 250 nM for human β₁-adrenergic receptors. Fasobegron can be used for the research of overactive bladder.

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CAS. Nr.: 643094-49-9
Formel: C₂₄H₂₄ClNO₄
Molecular Weight:425.91

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fasobegron Chemical Structure

CAS. Nr.: 643094-49-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

β3 adrenoceptor

4.8 nM (EC₅₀)

β1 adrenoceptor

250 nM (EC₅₀)

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	>1 μM Compound: 1a	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	>1 μM Compound: 9d	Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]
CHO	EC₅₀	250 nM Compound: 1a	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	251 nM Compound: 9d	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]
CHO	EC₅₀	4.8 nM Compound: 1a	Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	4.8 nM Compound: 8a	Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	[PMID: 18553954]
CHO	EC₅₀	4.8 nM Compound: 9d	Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]

In Vitro

Fasobegron (Compound 1a) potently and selectively activates human β₃-ARs in CHO cells, with an EC₅₀ of 4.8 nM, and exhibits >2000-fold selectivity over human β₂-ARs (EC50 >10000 nM) and ~52-fold selectivity over human β₁-ARs (EC50 = 250 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 643094-49-9
Molecular Weight 425.91
Formel C₂₄H₂₄ClNO₄
SMILES

O(C)C=1C=C(C=CC1C(O)=O)C2=CC=C(CCNC[C@H](O)C3=CC(Cl)=CC=C3)C=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Hattori K, et al. Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5. J Med Chem. 2009;52(9):3063-3072. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Fasobegron

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Fasobegron Related Classifications

HY-14767 Related Classifications