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Art. -Nr.: HY-163832

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FPPS-IN-2

FPPS-IN-2 (compound 4a) is a potent and orally active HFPPS inhibitor with an IC₅₀ value of 1.108 µM. FPPS-IN-2 has the potential for the research of osteoporosis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₄H₂₆O₆
Molecular Weight:410.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

FPPS-IN-2 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

FPPS-IN-2 (compound 4a) is a potent and orally active HFPPS inhibitor with an IC₅₀ value of 1.108 µM. FPPS-IN-2 has the potential for the research of osteoporosis^[1].

IC₅₀ & Target

IC₅₀: 1.108 µM (HFPPS)^[1]

In Vivo

FPPS-IN-2 (compound 4a) (0.1, 1, 10 mg/kg; p.o.; daily for 8 weeks) shows antiosteoporosis efficacy in ovariectomized rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

200-250 g, Female Wistar rats^[1]
Dosage:

0.1, 1, 10 mg/kg
Administration:

P.o.; daily for 8 weeks
Result:

Increased the osteocalcin level only with the 1, and 10 mg/kg doses, reduced urinary calcium.

Chemical Information

Molecular Weight 410.46
Formel C₂₄H₂₆O₆
SMILES

COC1=CC(/C=C/C(C)=O)=CC=C1OCCOC2=CC=C(/C=C/C(C)=O)C=C2OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. El-Sayed NF, et al. Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates. Eur J Med Chem. 2024 Jul 14;276:116679. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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