Efnb2 - ephrin B2 Gene

Also Known as Epl5; ELF-2; Eplg5; Htk-L; Lerk5; LERK-5; NLERK-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13642

Summary

Enables signaling receptor binding activity. Involved in several processes, including adherens junction organization; positive regulation of cardiac muscle cell differentiation; and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including negative regulation of keratinocyte proliferation; positive regulation of aorta morphogenesis; and vasculature development. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Is integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and urinary system. Orthologous to human EFNB2 (Ephrin B2). [provided by Alliance of Genome Resources, Apr 2022]

Efnb2 Products (2)

mRNA Protein Name
NM_001368299.1 NP_001355228.1 ephrin-B2 isoform 2
NM_010111.6 NP_034241.2 ephrin-B2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16511561 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
11780069 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within T cell costimulation IDA
IDA: Inferred from direct assay
15599401 MGI
involved in adherens junction organization IDA
IDA: Inferred from direct assay
30639848 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
15223334 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
19571816 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
19571816 MGI
acts upstream of or within lymph vessel development IMP
IMP: Inferred from mutant phenotype
15687262 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
19571816 MGI
acts upstream of or within nephric duct morphogenesis IMP
IMP: Inferred from mutant phenotype
25139858 MGI
acts upstream of or within positive regulation of aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
18952909 MGI
involved in positive regulation of cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
17336907 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
11754836 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: Inferred from mutant phenotype
11754836 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
19160501 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: Inferred from expression pattern
19160501 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
19160501 MGI
acts upstream of or within venous blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
18952909 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
11754836 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
11754836 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11754836 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
19160501 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
11754836 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15223334 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
14699416 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin-B2

  • EPH-related receptor tyrosine kinase ligand 5

  • HTK ligand

Recombinant Efnb2 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70378 Ephrin-B2/EFNB2 Protein, Mouse (HEK293, Fc-His) P52800 (R29-E227) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73017 Ephrin-B2/EFNB2 Protein, Mouse (HEK293, Fc) P52800/NP_034241.2 (R29-A232) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73018 Ephrin-B2/EFNB2 Protein, Mouse (HEK293, His) P52800 (R29-A232) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04198 EFNB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17275 Efnb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23729 Efnb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Efnb2 NCBI NCBI:1948