TIPARP - TCDD inducible poly(ADP-ribose) polymerase Gene

Also Known as PARP7; ARTD14; pART14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25976

About TIPARP

Cytogenetic location: 3q25.31 Genomic coordinates (GRCh38): 3:156,674,590-156,706,770 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and 8 paralogues. Ubiquitous expression in adrenal (RPKM 28.8), esophagus (RPKM 23.5) and 24 other tissues.

Summary

This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

TIPARP Products (6)

mRNA Protein Name
NM_001184717.1 NP_001171646.1 protein mono-ADP-ribosyltransferase TIPARP
XM_047447935.1 XP_047303891.1 protein mono-ADP-ribosyltransferase TIPARP isoform X1
XM_047447936.1 XP_047303892.1 protein mono-ADP-ribosyltransferase TIPARP isoform X2
NM_001184718.2 NP_001171647.1 protein mono-ADP-ribosyltransferase TIPARP
NM_015508.5 NP_056323.2 protein mono-ADP-ribosyltransferase TIPARP
XM_047447937.1 XP_047303893.1 protein mono-ADP-ribosyltransferase TIPARP isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
25043379 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
23275542 GOA
enables NAD+-protein-cysteine ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
30373764 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23275542 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
23275542 GOA
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23275542 GOA
acts upstream of or within positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
23275542 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
23275542 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIPARP Protein Structure

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (466 - 649)

  • 0
  • 200
  • 400
  • 600
  • 657 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase TIPARP

  • ADP-ribosyltransferase diphtheria toxin-like 14

  • poly [ADP-ribose] polymerase 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-181027 TIPARP-IN-1 Inhibitor / Unkown
HY-181629 ZSTK3744 / Unkown
HY-181629A ZSTK3744 hydrochloride / Unkown
HY-RS14546 TIPARP Human Pre-designed siRNA Set A / Unkown
HY-RS14547 Tiparp Mouse Pre-designed siRNA Set A / Unkown
HY-RS14548 Tiparp Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TIPARP VGNC VGNC:53609
Mus musculus TIPARP MGD MGI:2159210
Macaca mulatta TIPARP VGNC VGNC:82714
Felis catus TIPARP VGNC VGNC:102854
Canis familiaris TIPARP VGNC VGNC:52906
Rattus norvegicus TIPARP RGD RGD:1306171