SERPINE2 - serpin family E member 2 Gene

Also Known as GDN; PI7; PN1; PNI; PI-7; PN-1; GDNPF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5270

About SERPINE2

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:223,975,045-224,039,286 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 36 paralogues. Biased expression in placenta (RPKM 298.6), brain (RPKM 61.2) and 6 other tissues.

Summary

This gene encodes a member of the Serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

SERPINE2 Products (3)

mRNA	Protein	Name
NM_001136528.2	NP_001130000.1	glia-derived nexin isoform b precursor
NM_001136530.1	NP_001130002.1	glia-derived nexin isoform c precursor
NM_006216.4	NP_006207.1	glia-derived nexin isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables glycosaminoglycan binding	IDA IDA: Inferred from direct assay	19855083	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	1939253	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	3279057	GOA
enables serine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	3997857	GOA
enables serine-type endopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	19855083	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	17379830	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of blood coagulation	IDA IDA: Inferred from direct assay	17379830	GOA
involved in negative regulation of plasminogen activation	IMP IMP: Inferred from mutant phenotype	19855083	GOA
involved in negative regulation of proteolysis	IDA IDA: Inferred from direct assay	3997857	GOA
involved in positive regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	1691280	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	3279057	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19855083	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	3997857	GOA
located in platelet alpha granule	IDA IDA: Inferred from direct assay	19855083	GOA
located in platelet alpha granule	IMP IMP: Inferred from mutant phenotype	19855083	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINE2 Protein Structure

Serpin

0
100
200
300
398 a.a.

Protein Preferred Names	Protein Names
glia-derived nexin	glial-derived neurite promoting factor

SERPINE2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SERPINE2	P07093	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	SERPINE2	P07093	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	SERPINE2	P07093	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINE2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71085	Serpin E2 Protein, Human (HEK293, His)	P07093-2 (S20-P397)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Ciliary Dyskinesia, Primary, 27	Primary Ciliary Dyskinesia 27 CILD27 Ciliary Dyskinesia, Primary, 27, Without Situs Inversus Primary Ciliary Dyskinesia 27 Without Situs Inversus Primary Ciliary Dyskinesia 27 With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, 27
Ciliary Dyskinesia, Primary, 30	Primary Ciliary Dyskinesia 30 CILD30 Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus Primary Ciliary Dyskinesia 30 Without Situs Inversus Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, Type 30
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Kartagener Syndrome	Kartagener'S Syndrome
Ciliary Dyskinesia, Primary, 1	CILD1 Pcd Primary Ciliary Dyskinesia 1 Kartagener Syndrome Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus Immotile Cilia Syndrome Ics Polynesian Bronchiectasis Primary Ciliary Dyskinesia 1 With Or Without Situs Inversus Ics1 Immotile Cilia Syndrome 1 Primary Ciliary Dyskinesia KTGS Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome Kartagener Type Primary Ciliary Dyskinesia Kartagener Type Siewert Syndrome Immotile Cilia Dyskinesia, Ciliary, Primary, Type 1 Ciliary Motility Disorders
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS12723	SERPINE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17933	Serpine2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24403	Serpine2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SERPINE2	VGNC	VGNC:68839
Macaca mulatta	SERPINE2	VGNC	VGNC:77369
Canis familiaris	SERPINE2	VGNC	VGNC:46037
Mus musculus	SERPINE2	MGD	MGI:101780
Bos taurus	SERPINE2	VGNC	VGNC:56144
Rattus norvegicus	SERPINE2	RGD	RGD:3748
Others	SERPINE2	NCBI