RPA3 - replication protein A3 Gene

Also Known as REPA3; RP-A p14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6119

About RPA3

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:7,636,518-7,718,607 (from NCBI)

This gene has 7 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in lymph node (RPKM 9.0), bone marrow (RPKM 7.1) and 25 other tissues.

Summary

Enables damaged DNA binding activity and single-stranded DNA binding activity. Involved in DNA repair and DNA replication. Part of DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]

RPA3 Products (1)

mRNA Protein Name
NM_002947.5 NP_002938.1 replication protein A 14 kDa subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables damaged DNA binding IDA
IDA: Inferred from direct assay
7700386 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
2159011 GOA
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
19010961 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in DNA repair IDA
IDA: Inferred from direct assay
20545304 GOA
involved in DNA replication IMP
IMP: Inferred from mutant phenotype
9430682 GOA
involved in base-excision repair IDA
IDA: Inferred from direct assay
9765279 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
17765923 GOA
involved in mismatch repair IMP
IMP: Inferred from mutant phenotype
9430682 GOA
involved in nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
9430682 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of DNA replication factor A complex IDA
IDA: Inferred from direct assay
11927569 GOA
part of DNA replication factor A complex IPI
IPI: Inferred from physical interaction
7760808 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPA3 Protein Structure

Rep_fac-A_3

Rep_fac-A_3: Replication factor A protein 3 (5 - 113)

  • 0
  • 100
  • 121 a.a.
Protein Preferred Names Protein Names

replication protein A 14 kDa subunit

  • RF-A protein 3

RPA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RPA3 P35244 RPA4 Homo sapiens Q13156
Y2H
7760808
Intra
RPA3 P35244 RPA1 Homo sapiens P27694
TAP
24126761
Intra
RPA3 P35244 RPA2 Homo sapiens P15927
Pull Down
10982866
Intra
RPA3 P35244 RPA2 Homo sapiens P15927
X-Ray Diffraction
10449415
Intra
RPA3 P35244 RPA2 Homo sapiens P15927
Y2H
15965237
Intra
RPA3 P35244 RPA2 Homo sapiens P15927
Y2H
10982866
Intra
RPA3 P35244 RPA2 Homo sapiens P15927
TAP
24126761
Intra
RPA3 P35244 RAD52 Homo sapiens P43351
TAP
24126761
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rheumatoid Arthritis Interstitial Lung Disease

  • Rheumatoid Lung
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12144 RPA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21426 Rpa3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27944 Rpa3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RPA3 VGNC VGNC:34096
Rattus norvegicus RPA3 RGD RGD:1306810
Mus musculus RPA3 MGD MGI:1915490
Felis catus RPA3 VGNC VGNC:80672
Canis familiaris RPA3 VGNC VGNC:45704
Others RPA3 NCBI