RPA4 - replication protein A4 Gene

Also Known as HSU24186

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29935

About RPA4

Cytogenetic location: Xq21.33 Genomic coordinates (GRCh38): X:96,883,908-96,885,467 (from NCBI)

This gene has 1 transcript (splice variant), 25 orthologues and 2 paralogues.

Summary

This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]

RPA4 Products (1)

mRNA Protein Name
NM_013347.4 NP_037479.1 replication protein A 30 kDa subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7760808 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IDA
IDA: Inferred from direct assay
19942684 GOA
involved in DNA repair IDA
IDA: Inferred from direct assay
20545304 GOA
NOT involved in nuclear DNA replication IDA
IDA: Inferred from direct assay
19116208 GOA
involved in nucleotide-excision repair IDA
IDA: Inferred from direct assay
19996105 GOA
Cellular Component GO Annotation Evidence References Source
part of DNA replication factor A complex IDA
IDA: Inferred from direct assay
19116208 GOA
part of DNA replication factor A complex IPI
IPI: Inferred from physical interaction
7760808 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19942684 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPA4 Protein Structure

tRNA_anti-codon

tRNA_anti-codon: OB-fold nucleic acid binding domain (74 - 148)

RPA_C

RPA_C: Replication protein A C terminal (165 - 255)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

replication protein A 30 kDa subunit

  • RF-A protein 4

RPA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPA4 Q13156 PTRHD1 Homo sapiens Q6GMV3
Validated Y2H
32296183
Intra
RPA4 Q13156 RPA1 Homo sapiens P27694
Anti Tag CoIP
28514442
Intra
RPA4 Q13156 RPA1 Homo sapiens P27694
Anti Tag CoIP
33961781
Intra
RPA4 Q13156 RPA3 Homo sapiens P35244
Anti Tag CoIP
33961781
Intra
RPA4 Q13156 RPA3 Homo sapiens P35244
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12145 RPA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown