TPO - thyroid peroxidase Gene

Also Known as MSA; TPX; TDH2A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7173

About TPO

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:1,374,047-1,543,673 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 201 orthologues, 5 paralogues and is associated with 2 phenotypes. Restricted expression toward thyroid (RPKM 463.8).

Summary

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid Hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

TPO Products (6)

mRNA	Protein	Name
NM_000547.6	NP_000538.3	thyroid peroxidase isoform a precursor
NM_001206744.2	NP_001193673.1	thyroid peroxidase isoform a precursor
NM_001206745.2	NP_001193674.1	thyroid peroxidase isoform b precursor
NM_175719.4	NP_783650.1	thyroid peroxidase isoform b precursor
NM_175721.3	NP_783652.1	thyroid peroxidase isoform d precursor
NM_175722.3	NP_783653.1	thyroid peroxidase isoform e precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Verweise	Source
involved in embryonic hemopoiesis	IDA IDA: Inferred from direct assay	21149635	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPO Protein Structure

An_peroxidase

EGF_CA

0
200
400
600
800
933 a.a.

Protein Preferred Names	Protein Names
thyroid peroxidase	thyroid microsomal antigen

Recombinant TPO Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P73582	TPO/Thyroid peroxidase Protein, Human (A257S, T725P, sf9, His)	P07202-1 (C15-R846, A257S, T725P)	≥ 95%, as determined by reducing SDS-PAGE.

TPO Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81735	Thyroid Peroxidase Antibody (YA1480)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Thyroid Dyshormonogenesis 2a	TDH2A Iodide Peroxidase Deficiency Deficiency Of Iodide Peroxidase Thyroid Peroxidase Deficiency Genetic Defect In Thyroid Hormonogenesis 2a Thyroid Hormonogenesis, Genetic Defect In, 2a Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2a Chdh2a Congenital Hypothyroidism Due To Dyshormonogenesis Type 2a Thyroid Hormone Organification Defect 2 Tiod
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Familial Thyroid Dyshormonogenesis	Thyroid Dyshormonogenesis Familial Dyshormonogenetic Goiter
Goiter	Goitre
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Endemic Goiter	Iodine-Deficiency-Related Endemic Goitre Simple Goitre Goiter, Endemic Euthyroid Goiter
Thyroiditis	Inflammation Of Thyroid Thyroiditis Nos
Graves' Disease	Graves Disease Exophthalmic Goiter Basedow'S Disease Grave'S Disease Basedow Disease Toxic Diffuse Goiter Graves' Hyperthyroidism Parry Disease Autoimmune Hyperthyroidism Toxic Multinodular Goiter
Hyperthyroidism	Overactive Thyroid
Subacute Thyroiditis	Giant-Cell Thyroiditis Granulomatous Thyroiditis Subacute Granulomatous Thyroiditis De Quervain'S Thyroiditis Thyroiditis Subacute Thyroiditis, Subacute Pseudogranulomatous Thyroiditis De Quervain Thyroiditis Nonsuppurative Subacute Thyroiditis Pseudotuberculous Thyroiditis Nonsuppurative Thyroiditis Nos
Nodular Goiter	Goiter, Nodular Nodular Goitre Goiter Nodular Non-Toxic Nodular Goiter
Multinodular Goiter
Plummer'S Disease	Toxic Nodular Goiter Plummer Disease Goiter Toxic Nodular
Hyperthyroxinemia
Toxic Diffuse Goiter
Follicular Adenoma	Follicular Adenoma Of The Thyroid Gland Thyroid Follicular Adenoma Adenoma Follicular Follicular Thyroid Adenoma Thyroid Gland Follicular Adenoma
Myxedema
Nontoxic Goiter	Goiter, Non-Toxic Goitre, Non-Toxic Nodule-Thyroid, Non Tox Non-Toxic Goitre Non-Toxic Simple Goitre Goitre Nos Goitre Struma Enlarged Thyroid Gland Thyromegaly Thyroid Hypertrophy Thyroid Gland Hypertrophy Thyroid Hyperplasia Thyroid Gland Hyperplasia Swelling Of Thyroid Gland Substernal Thyroid Mass Substernal Goitre Substernal Thyroid Retrosternal Thyroid Struma Sporadic Nodular Struma Struma Of Thyroid Retrosternal Goitre Plunging Goitre Nontoxic Nodular Goitre Nodular Struma Form Of Goitre Hyperplastic Goitre Hypertrophic Thyroid Intrathoracic Goitre Nodular Goitre
Hashimoto Thyroiditis	Autoimmune Thyroiditis Hashimoto Struma Hashimoto'S Thyroiditis Chronic Lymphocytic Thyroiditis Lymphocytic Thyroiditis Hashimoto Disease Ht Hashimoto'S Disease Hashimoto'S Syndrome Hypothyroidism, Autoimmune Autoimmune Chronic Lymphocytic Thyroiditis Chronic Lymphocytic Thyroiditides Hashimoto Syndrome Hashimotos Thyroiditis Hashimoto Thyroiditis, Susceptibility To Thyroiditis, Autoimmune Lymphomatous Thyroiditis Lymphoid Thyroiditis Chronic Lymphadenoid Thyroiditis Autoimmune Lymphocytic Chronic Thyroiditis Goitre Lymphomatosa Hashitoxicosis Hashimoto Hypothyroidism Lymphadenoid Goitre Struma Lymphomatosa Hyperthyroidism With Hashimoto Disease Hashimoto Thyrotoxicosis Thyrotoxicosis Due To Hashimoto Thyroiditis Struma Lymphomatosis Lymphadenoid Struma
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Pernicious Anemia	Anemia, Pernicious Anemia Pernicious Pernicious Anaemia Addison'S Anaemia Biermer'S Anaemia Biermer'S Anemia Acquired Pernicious Anemia Addison-Biermer Anemia Addisonian Anemia Biermer Anemia Biermer'S Disease Juvenile Onset Pernicious Anemia Biermer Disease Biermer-Addison Disease
Papillary Carcinoma	Carcinoma, Papillary Carcinoma Papillary
Tracheopathia Osteoplastica	Tracheobronchopathia Osteochondroplastica Tracheobronchopathia Osteoplastica Cartilaginous Or Bony Projections Into The Tracheobronchial Lumen
Postpartum Depression	Maternity Blues Postnatal Depression Depression, Postpartum Post-Partum Depression Depression Postpartum
Iodine Hypothyroidism	Iodine Deficiency Hypothyroidism
Turner Syndrome	Monosomy X Gonadal Dysgenesis Turner Type Ullrich-Turner Syndrome Bonnevie-Ullrich Syndrome Karyotype 45, X Genital Dwarfism, Turner Type Gonadal Dysgenesis 45,X Turner'S Syndrome Gonadal Dysgenesis - Turner Monosomy X Syndrome Xo Syndrome Genital Dwarfism 45, X Syndrome Bonnevie-Ulrich Syndrome Chromosome X Monosomy X Schereshevkii Turner Syndrome Turner Varny Syndrome Ts 45,X Syndrome 45,X/46,Xx Syndrome Turners Syndrome Gonadal Dysgenesis, 45,X X0 Syndrome
Hypoadrenocorticism, Familial	Addison Disease Primary Adrenocortical Insufficiency Addison'S Disease Adrenal Gland Hypofunction Adrenal Hypoplasia Adrenal Aplasia Addison Disease, Chronic Adrenal Insufficiency Primary Hypoadrenalism Hypoadrenocorticism Familial Autoimmune Addison Disease Autoimmune Adrenalitis Classic Addison Disease Primary Addison Disease Addisons Disease Addison Disease, Susceptibility To Autoimmune Primary Adrenal Insufficiency Addison'S Disease Due To Autoimmunity
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Mechanical Strabismus	Strabismus Acquired Deformity Of Ocular Muscle
Limbic Encephalitis
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Thyroid Lymphoma
Postsurgical Hypothyroidism	Postoperative Hypothyroidism Post-Surgical Hypothyroidism
Graves Disease 1	Thyrotoxicosis Graves Disease, Susceptibility To, 1 GRD1 Grd Hyperthyroidism, Autoimmune Hyperthyroidism Hyperactive Thyroid Gland Overactive Thyroid Toxic Diffuse Goitre Toxic Primary Thyroid Hyperplasia Stokes Disease Thyrotoxicosis With Goitre Thyrotoxicosis Struma Graves Disease Goitre With Hyperthyroidism Basedow Disease Exophthalmic Goitre Exophthalmic Struma Flajani Disease Graves Disease With Exophthalmos Hyperthyroid Goitre Hyperthyroidism Struma Thyroid Exophthalmos Malignant Exophthalmos Parry Disease Toxic Diffuse Goitre With Exophthalmos Toxic Goitre Toxic Goitre Nos Thyrotoxicosis Due To Uninodular Goitre Toxic Thyroid Nodule Toxic Uninodular Goitre Uninodular Toxic Struma Uninodular Toxic Struma With Hyperthyroidism Thyrotoxicosis Due To Single Thyroid Nodule Toxic Uninodular Goitre With Hyperthyroidism Hyperthyroidism With Thyroid Nodule Thyrotoxicosis With Toxic Uninodular Goitre Uninodular Goitre In Hyperthyroidism Uninodular Goitre In Thyrotoxicosis Toxic Multinodular Goitre Multinodular Goitre With Thyrotoxicosis Thyrotoxicosis Nodular Goitre Nodular Goitre With Thyrotoxicosis Adenomatous Goitre With Hyperthyroidism Multinodular Goitre With Hyperthyroidism Nodular Goitre With Hyperthyroidism Nodular Struma With Hyperthyroidism Plummer Disease Thyrotoxicosis Adenomatous Goitre Thyrotoxicosis Adenomatous Struma Toxic Adenomatous Goitre Toxic Adenomatous Struma Toxic Nodular Goitre Nos Toxic Struma Nodosa Toxic Nodular Struma
Chronic Urticaria	Urticaria Chronic Chronic Spontaneous Urticaria Chronic Ordinary Urticaria
Acute Thyroiditis	Infectious Thyroiditis
Pendred Syndrome	Goiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness
Autoimmune Disease Of Endocrine System
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors	Euthyroid Goiter MNG1 Simple Goiter Goiter Euthyroid Goiter, Nontoxic, With Intrathyroidal Calcification Multinodular Goiter, Adolescent Familial Multinodular Goiter Fmng Familial Mng Familial Multinodular Goiter Syndrome Goiter Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors Goiter Nontoxic With Intrathyroidal Calcification Goiter Non-Toxic With Intrathyroidal Calcification Multinodular Goiter Adolescent Goiter, Multinodular, Type 1, With/Without Sertoli-Leydig Cell Tumors Endemic Goiter
Chronic Inducible Urticaria
Thyroid Gland Disease	Abnormality Of The Thyroid Gland Thyroid Diseases
Autoimmune Hepatitis	Aih Hepatitis, Autoimmune Autoimmune Chronic Active Hepatitis Autoimmune Hepatitis With Centrilobular Necrosis Autoimmune Chronic Hepatitis Hepatitis Autoimmune
Hypoparathyroidism	Hypoparathyroidism, Idiopathic Parathyroid, Underactivity Of Syndrome With Hypoparathyroidism Deficiency Of Parathyroid Hormone Parathyroid Gland Insufficiency Parathyroid Insufficiency Hypoparathyroidism Due To Impaired Pth - [Parathyroid Hormone] Secretion
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1	Vitiligo VAMAS1 Slev1 Vtlg Systemic Lupus Erythematosus, Vitiligo-Related Vitiligo-Associated Multiple Autoimmune Disease 1 Systemic Lupus Erythematosus Vitiligo-Related
Thyroid Crisis	Thyrotoxic Crisis Thyroid Storm Thyrotoxic Storm
Suppurative Thyroiditis	Thyroiditis, Suppurative Acute Suppurative Thyroiditis Infectious Thyroiditis
Chronic Spontaneous Urticaria	Chronic Idiopathic Urticaria
Aspirin Allergy	Acetylsalicylic Acid Allergy Asa Allergy
Alopecia Areata	Aa Alopecia Celsi Alopecia Circumscripta Cazenave'S Vitiligo Celsus' Vitiligo Diffuse Alopecia Jonston'S Alopecia Marginal Alopecia Pseudopelade Circumscribed Alopecia Alopecia Cicatrisata Patchy Alopecia Alopecia Aa - [Alopecia Areata] Pelade
Adrenal Cortical Hypofunction	Adrenal Cortical Insufficiency Corticoadrenal Insufficiency
Dermatographia	Dermatographic Urticaria Dermographism Symptomatic Dermographism Urticaria Factitia Factitious Urticaria Dermatographism
Hypotropia
Subacute Lymphocytic Thyroiditis
Exophthalmos	Proptosis
Hypothyroidism, Congenital, Nongoitrous, 4	Tsh Deficiency CHNG4 Thyrotropin Deficiency, Isolated Pituitary Cretinism Congenital Nongoitrous Hypothyroidism 4 Isolated Thyrotropin Deficiency Thyroid-Stimulating Hormone Deficiency Hypothyroidism, Congenital, Nongoitrous 4 Thyroid-Stimulating Hormone, Deficiency Of Isolated Thyroid-Stimulating Hormone Deficiency Isolated Tsh Deficiency Hypothyroidism, Congenital, Nongoitrous, Type 4 Secondary Hypothyroidism Tsh - [Thyroid Stimulating Hormone] Deficiency
Viral Hepatitis	Animal Viral Hepatitis Hepatitis, Viral, Animal Human Viral Hepatitis Viral Hepatitis With Hepatic Coma
Nonencapsulated Sclerosing Carcinoma	Nonencapsulated Sclerosing Neoplasm Papillary Carcinoma, Diffuse Sclerosing
Cholinergic Urticaria
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Autoimmune Gastritis
Polycystic Kidney Disease 4
Infertility
Microcephaly And Chorioretinopathy 1
Orbital Plasma Cell Granuloma	Orbital Myositis Orbital Pseudotumor Pseudotumor Of Orbit Plasma Cell Granuloma, Orbital
Thyrotoxic Exophthalmos
Chronic Orbital Inflammation	Chronic Inflammation Of Orbit
Endocrine Exophthalmos	Endocrine Exopthalmos Thyroid Associated Opthalmopathies
Thyroid Gland Follicular Carcinoma	Follicular Thyroid Carcinoma Follicular Adenocarcinoma Follicular Adenocarcinoma, Well Differentiated Follicular Carcinoma Thyroid Adenocarcinoma Adenocarcinoma, Follicular
Cataract 9, Multiple Types	Cataract 9 Multiple Types CTRCT9 Cataract, Autosomal Dominant Catc1 Cataract 9, Multiple Types, With Or Without Microcornea Cataract, Autosomal Recessive Congenital 1 Autosomal Recessive Congenital Cataract 1 Cataract 9 Multiple Types With Or Without Microcornea Autosomal Dominant Congenital Cataract Cataract Autosomal Dominant Cataracts, Autosomal Dominant
Adrenal Cortex Disease	Adrenal Cortex Diseases
Immunodeficiency 58	IMD58 Severe Combined Immunodeficiency Due To Carmil2 Deficiency Combined Immunodeficiency Due To Carmil2 Deficiency Combined Immunodeficiency Due To Rltpr Deficiency
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Dystonia 25	DYT25 Dystonia-25 Dystonia, Type 25
Torsion Dystonia 2	Dystonia 2, Torsion, Autosomal Recessive
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Methylmalonic Aciduria, Cbla Type	Methylmalonic Acidemia Cbla Type Methylmalonic Aciduria Cbla Type Methylmalonic Acidemia, Cbla Type Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cbla Type Methylmalonic Aciduria, Vitamin B12-Responsive, Cbla Type Methylmalonic Aciduria, Vitamin B12-Responsive Due To A Defect In Synthesis Of Adenosylcobalamin Cb1a Type Vitamin B12-Responsive Methylmalonic Acidemia Type Cbla Vitamin B12-Responsive Methylmalonic Aciduria Type Cbla Methylmalonic Aciduria Type Cbla MMAA Methylmalonic Aciduria Type A Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl A Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl A Aciduria, Methylmalonic, Cbla Type Methylmalonic Aciduria Cbla Type
Necrotizing Gastritis
Diabetes Mellitus	Diabetes
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-13463	Avatrombopag	Agonist	99.83%	Yes
HY-19883	Lusutrombopag	Agonist	98.05%	Unkown
HY-W017113	2-Mercaptobenzothiazole		99.85%	Yes
HY-13463A	Avatrombopag maleate		99.99%	Yes
HY-13463B	Avatrombopag hydrochloride	Agonist	97.05%	Yes

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-145581	Mitiperstat	Inhibitor	99.12%	Phase 3

Pre-clinical Phase

Bioactive Molecules (19)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-148748	Butyzamide	Activator	99.83%	Unkown
HY-W017894	TPO-L		99.77%	Unkown
HY-112486	TA-316		99.50%	Unkown
HY-112486G	TA-316 (GMP)	Agonist	/	Unkown
HY-100380	TPO agonist 1	Agonist	98.0%	Unkown
HY-148748G	Butyzamide (GMP)	Activator	/	Unkown
HY-139915	MPO-IN-1	Inhibitor	98.07%	Unkown
HY-15306S	Eltrombopag-13C4		97.89%	Unkown
HY-19883S	Lusutrombopag-d13	Agonist	98.64%	Unkown
HY-13463BS	Avatrombopag-d8 hydrochloride	Agonist	/	Unkown
HY-145581B	(rac)-Mitiperstat	Inhibitor	98.25%	Unkown
HY-145581S	Mitiperstat-d3	Inhibitor	/	Unkown
HY-147691	MPO-IN-5	Inhibitor	/	Unkown
HY-153239	Eltrombopag methyl ester	Agonist	/	Unkown
HY-RS14498	THPO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14941	TPO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16596	Tpo Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17819	Thpo Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23030	Tpo Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990685	Romiplostim	Agonist	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TPO	VGNC	VGNC:78636
Felis catus	TPO	VGNC	VGNC:66480
Mus musculus	TPO	MGD	MGI:98813
Canis familiaris	TPO	VGNC	VGNC:47746
Rattus norvegicus	TPO	RGD	RGD:3900
Others	TPO	NCBI