EPX - eosinophil peroxidase Gene

Also Known as EPO; EPP; EPXD; EPX-PEN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8288

About EPX

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,192,726-58,205,174 (from NCBI)

This gene has 1 transcript (splice variant), 310 orthologues, 5 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 13.2) and spleen (RPKM 0.3).

Summary

This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic Infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with Other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]

EPX Products (1)

mRNA	Protein	Name
NM_000502.6	NP_000493.1	eosinophil peroxidase preproprotein

EPX Protein Structure

An_peroxidase

0
200
400
600
715 a.a.

Protein Preferred Names	Protein Names
eosinophil peroxidase

EPX Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81194	EPX Antibody	IHC-P, IHC-F, ICC/IF	Human, Mouse

Related Diseases

Diseases	Alias
Eosinophil Peroxidase Deficiency	Presentey Anomaly EPXD Peroxidase And Phospholipid Deficiency In Eosinophils Eosinophil Peroxidase Deficiency, Partial Partial Eosinophil Peroxidase Deficiency
Proctitis	Ulcerative Proctitis Chronic Ulcerative Proctitis Idiopathic Proctitis Nonspecific Ulcerative Proctitis Ulcerative Colitis Confined To Rectum Ip - [Idiopathic Proctitis] Chronic Ulcerative Proctitis Nos
Hypereosinophilic Syndrome	Eosinophilia HES Eosinophilic Leukocytosis Hypereosinophilic Syndrome, Idiopathic Idiopathic Hypereosinophilic Syndrome Disseminated Eosinophilic Collagen Disease Eosinophilic Disorder Disorders With Increased Eosinophil Counts
Onchocerciasis	Infection By Onchocerca Volvulus River Blindness Onchocerca Volvulus Infection Volvulosis Robles' Disease Onchocerciasis, Ocular Robles Disease Onchocercosis Blinding Filariasis Robles Onchocerca Infestation Craw-Craw
Food Allergy	Food Hypersensitivity Food Allergies Allergy Food Food Allergen-Induced Hypersensitivity
Allergic Rhinitis	Hay Fever Allergic Rhinitis, Susceptibility To ALRH Atopic Rhinitis Seasonal Allergic Rhinitis Non-Seasonal Allergic Rhinitis Perenial Allergic Rhinitis Pollenosis Rhinitis Allergic Seasonal Rhinitis, Allergic, Perennial Allergic Rhinitis, Cause Unspecified Pollinosis Pollen Allergy Allergy Nos Due To Pollen Summer Catarrh Other Seasonal Allergic Rhinitis
Urinary Schistosomiasis	Schistosoma Haematobium Infection Schistosoma Hematobium Infection Schistosomiasis Due To Schistosoma Haematobium Bladder Schistosomiasis Cystitis With Bilharziasis Schistosoma Haematobium Schistosoma Hematobium Infectious Disease Schistosomiasis Of Bladder Vesical Schistosomiasis Schistosomiasis Urinary Schistosomiasis Haematobia Genitourinary Bilharziasis Genitourinary Tract Schistosomiasis Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis] Haematochyluria In Schistosomiasis Infection Due To Schistosoma Matthei
Childhood-Onset Asthma	Childhood Asthma Asthma Childhood
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Rhinitis	Runny Nose
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Allergic Bronchopulmonary Aspergillosis	Aspergillosis, Allergic Bronchopulmonary Abpa Allergic Bronchopulmonary Mycosis Hinson-Pepys Disease Pulmonary Aspergillus Disease Allergic Aspergillosis Aspergillosis Allergic Bronchopulmonary
Endocarditis
Pulmonary Eosinophilia	Asthmatic Pulmonary Eosinophilia Eosinophilic Lung Infiltrate Weingarten'S Syndrome
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus
Eosinophilic Gastritis	Eosinophilic Enteropathy
Endomyocardial Fibrosis	Becker'S Disease Obscure African Cardiomyopathy African Endomyocardial Fibrosis Endomyocardial Sclerosis EMF Becker Muscular Dystrophy
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Esophagitis, Eosinophilic, 1	Eosinophilic Esophagitis EOE1 Esophagitis, Eosinophilic Ee
Conjunctivitis	Madras Eye Adenoviral Conjunctivitis Acute Adenoviral Follicular Conjunctivitis Inclusion Conjunctivitis Of The Adult Swimming-Pool Conjunctivitis Inflammation Of Conjunctiva Ophthalmia Acute Conjunctivitis Eye Catarrh Catarrhal Ophthalmia Koch-Weeks Conjunctivitis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Eosinophilic Gastroenteritis	Eosinophilic Enteritis Ege Eosinophilic Gastroenterocolitis Eosinophilic Esophagitis Eosinophilic Gastritis Eosinophilic Gastroenteropathy Gastroenteritis, Eosinophilic Eosinophilic Enteropathy
Chronic Eosinophilic Pneumonia	Carrington Syndrome Idiopathic Chronic Eosinophilic Pneumonia Cryptogenic Pulmonary Eosinophilia Idiopathic Eosinophilic Chronic Pneumopathy Carrington'S Disease Carrington'S Pulmonary Eosinophilia Chronic Idiopathic Eosinophilic Pneumonia Eosinophilic Idiopathic Chronic Pneumopathy Eosinophilic Pneumonia Chronic
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Disseminated Eosinophilic Collagen Disease
Loiasis	Loa Loa Filariasis Mansonelliasis African Eye Worm Mansonella Perstans Infections Mansonellosis Eye Worm Disease Of Africa Loa Loa Infestation African Eyeworm Disease Calabar Swelling
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Acute Asthma
Respiratory Allergy	Airway Allergy
Chronic Asthma
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Nasal Cavity Disease	Disorder Of Nasal Cavity
Nose Disease	Nose Diseases Disorder Of The Nose Nasal Disorder Abnormality Of The Nose
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Parasitic Helminthiasis Infectious Disease	Helminthiasis Intestinal Helminthiasis Helminth Infection Helminthosis Worm Infection Worm Infections Helminth Infections Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata Parasitic Enteritis Metazoal Dysentery Intestinal Worms Nos
Restrictive Cardiomyopathy	Familial Restrictive Cardiomyopathy Cardiomyopathy, Restrictive Cardiomyopathy, Constrictive Primary Restrictive Cardiomyopathy Rcm Cardiomyopathy Restrictive
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS04459	EPX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EPX	VGNC	VGNC:72250
Rattus norvegicus	EPX	RGD	RGD:1311882
Mus musculus	EPX	MGD	MGI:107569
Others	EPX	NCBI