GS-6620
Based on 1 Customer Validation
GS-6620 is potent and selective HCV inhibitor. GS-6620 inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM. GS-6620 can be used for the researches of infection and inflammation, such as Hepatitis C Virus (HCV).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.93%
- CAS. Nr.: 1350735-70-4
- Formel: C29H37N6O9P
- Molecular Weight:644.61
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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GT3a 0.048 μM (EC50) |
GT4a 0.11 μM (EC50) |
GT6a 0.11 μM (EC50) |
GT5a 0.14 μM (EC50) |
GT1a 0.18 μM (EC50) |
GT1b 0.46 μM (EC50) |
GT2a 0.68 μM (EC50) |
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Cell Line
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Type | Value | Description | References |
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| HeLa | EC50 |
>20 μM
Compound: 13b
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Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay
Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay
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[PMID: 28124907] |
| HEp-2 | CC50 |
95 μM
Compound: 13b
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Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
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[PMID: 28124907] |
| Huh-7 | CC50 |
47 μM
Compound: 16
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Cytotoxicity against human HuH7 cells after 3 days by fluorescence assay
Cytotoxicity against human HuH7 cells after 3 days by fluorescence assay
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[PMID: 23547794] |
| Huh-7 | CC50 |
51 μM
Compound: 13b
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Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 3 days by calcein-AM dye based fluorescence assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 3 days by calcein-AM dye based fluorescence assay
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[PMID: 28124907] |
| Huh-7 | EC50 |
0.61 μM
Compound: 16
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Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luminescence assay
Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luminescence assay
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[PMID: 23547794] |
| MT4 | CC50 |
7.8 μM
Compound: 13b
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Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
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[PMID: 28124907] |
GS-6620 (72 h) inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM and shows weak activity against bovine viral diarrhea virus (BVDV, EC50 = 1.5 μM)[1].
GS-6620 (active metabolite) (0.39-1.3 μM, 70-90 mins) inhibits HCV NS5B polymerase[1].
GS-6620 (0-100 μM, 5 days) shows low cytotoxicity in Huh-7, HepG2, PC-3 and PBMCs with CC50 values of 67, 66, 40 and >100 μM[1].
GS-6620 (20-100 μM, 5-10 days) does not reduce mitochondrial DNA content in HepG2 cells or inhibit mitochondrial protein synthesis in PC-3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1350735-70-4
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Appearance Solid
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Molecular Weight 644.61
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Formel C29H37N6O9P
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Color White to off-white
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SMILES
NC1=NC=NN2C1=CC=C2[C@@]3(C#N)[C@@](O)(C)[C@H](OC(C(C)C)=O)[C@@H](CO[P@](OC4=CC=CC=C4)(N[C@@H](C)C(OC(C)C)=O)=O)O3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Joy Y Feng, et al. Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrob Agents Chemother. 2014;58(4):1930-42. [Content Brief]
[2]. Cho A, et al. Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients. J Med Chem. 2014 Mar 13;57(5):1812-25. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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