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United States

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Art. -Nr.: HY-180538

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MRT-31619

MRT-31619 is a selective CRBN Molecular glue degrader, with an IC₅₀ of 14 nM and an EC₅₀ of 72 nM. MRT-31619 triggers ubiquitination and proteasomal degradation of CRBN. MRT-31619 serves as a chemical knockout tool for CRBN depletion to evaluate the dependence of other molecular glues on CRBN. MRT-31619 is applicable to the research of CRBN-related disease models.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₈H₃₀N₄O₄
Molecular Weight:486.56

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

MRT-31619 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

CRBN

14 nM (IC₅₀)

In Vitro

MRT-31619 (1-10 μM; 1-24 h) potently and selectively degrades CRBN in Jurkat cells: this effect occurs after treatment at 1 μM for 1 h, 3 h and 24 h, as well as after treatment at 10 μM for 24 h, without affecting the level of DDB1^[1].
Incubation of purified recombinant CRBN-DDB1 complex with MRT-31619 (10 μM; 60 min) induces the formation of CRBN-DDB1 dimeric complex^[1].
MRT-31619 induces the formation of CRBN ternary complex, with an EC₅₀ of 72 nM as determined by FIDA assay using purified recombinant CRBN-DDB1 complex^[1].
MRT-31619 efficiently and selectively degrades CRBN via a self-targeting mechanism involving CRBN homodimerization, with a CRBN-binding IC₅₀ of 14 nM and a complex-formation EC₅₀ of 72 nM in Jurkat cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 486.56
Formel C₂₈H₃₀N₄O₄
SMILES

O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=C(C=C3)N4CCC5(C4)CCN(CC5)C(C6=CC=CC=C6)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 1.25 mg/mL (2.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0552 mL

10.2762 mL

20.5525 mL

5 mM

---

10 mM

---

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Langousis G, et al. A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation. Nature communications. 2025 Nov 19;16(1):10157. [Content Brief]

[2]. Won H J, et al. Synthetic and Medicinal Chemistry Perspectives on Cereblon‐Binding Molecular Glue Degraders: Recent Advances and Emerging Trends[J]. European Journal of Organic Chemistry, 2026, 29(17): e202501208.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0552 mL	10.2762 mL	20.5524 mL	51.3811 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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