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Art. -Nr.: HY-161873

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PW507

PW507 is a potent, brain-penetrant and selective sigma 1 receptor (S1R) antagonist with a K_i of 7.5 nM for human S1R. PW507 displays a low binding affinity to S2R and hERG. PW507 can be used for the study of painful diabetic neuropathy (PDN).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2573850-59-4
Formel: C₁₈H₂₇ClN₄
Molecular Weight:334.89

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PW507 Chemical Structure

CAS. Nr.: 2573850-59-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Sigma Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

PW507 binds to the orthosteric site of the human S1R crystal structure and engages in strong interactions with the receptor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PW507 (20 mg/kg; i.p; twice daily; for 14 days) demonstrates significant efficacy in alleviating mechanical allodynia hyperalgesia^[1].
PW507’s Pharmacokinetic Properties in SD rats Studies^[1].
1.19

plasma PK	IV	PO	IP
dose (mg/kg)	1	25	10
t_max (h)	N/A	1.20	0.25
t_1/2 (h)	0.53	0.69	0.56
C_max (ng/mL)	193	296	671
AUC_0-inf (h*ng/mL)	108	692	552
CL (mL/min/kg)	155	N/A	N/A
ratio (brain/plasma, t = 0.25 h)	N/A	N/A	12
F (%)	100	28	51

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male SD rats injected Streptozotocin (HY-13753; STZ; 60 mg/kg)^[1]
Dosage:

20 mg/kg
Administration:

i.p; twice daily; for 14 days
Result:

Demonstrated significant efficacy in alleviating mechanical allodynia hyperalgesia.

Chemical Information

CAS. Nr. 2573850-59-4
Molecular Weight 334.89
Formel C₁₈H₂₇ClN₄
SMILES

CC(C)(C)C1=CC=C(C2=NC(CN3CCCC3)=NN2C)C=C1.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Youyi Peng, et al. Preclinical Evaluation of Sigma 1 Receptor Antagonists as a Novel Treatment for Painful Diabetic Neuropathy. ACS Pharmacol. Transl. Sci. July 18, 2024.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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