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Art. -Nr.: HY-148921

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SDH-IN-2

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Based on 1 Customer Validation

SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC₅₀ values of 3.82-9.81 μg/mL for all the fungi. SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Reinheit: 99.07%
CAS. Nr.: 1823354-06-8
Formel: C₁₀H₆F₃NO
Molecular Weight:213.16

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SDH-IN-2 Chemical Structure

CAS. Nr.: 1823354-06-8

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC₅₀ values of 3.82-9.81 μg/mL for all the fungi^[1]. SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

SDH-IN-2 (Compound 13) (200 μg/mL, 7 days) completely inhibits Physalospora piricola infection on apples, and also shows high inhibition rates of 70.9-86.9% on all the fungi even at 20 μg/mL^[1].
SDH-IN-2 inhibits P. oryza and F. oxysporum f. sp. niveum with EC₅₀s of 4.33 and 3.56 μg/mL^[1].
SDH-IN-2 (0-50 μg/mL) has no effect on the germination rate of bean seeds^[1].
SDH-IN-2 (0-100 μg/mL) has no significant effect on the growth of wheat seedlings^[1].
SDH-IN-2 inhibits SDH enzymatic activity with an IC₅₀ of 0.55 μg/mL^[1].
SDH-IN-2 binds well to the ubiquinone-binding region of SDH by hydrogen bonds and undergoes π–alkyl interaction and π-cation interaction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SDH-IN-2 (Compound 13) (0-200 μg/mL, 7 days) inhibits the infection of P. piricola on apples^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1823354-06-8
Appearance Solid
Molecular Weight 213.16
Formel C₁₀H₆F₃NO
Color Off-white to light yellow
SMILES

O=C(NC1=CC=C(C(F)(F)F)C=C1)C#C
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 250 mg/mL (1172.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.6913 mL

23.4566 mL

46.9131 mL

5 mM

0.9383 mL

4.6913 mL

9.3826 mL

10 mM

0.4691 mL

2.3457 mL

4.6913 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang YH, et al. Discovery of N-Phenylpropiolamide as a Novel Succinate Dehydrogenase Inhibitor Scaffold with Broad-Spectrum Antifungal Activity on Phytopathogenic Fungi. J Agric Food Chem. 2023 Mar 1;71(8):3681-3693. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.6913 mL	23.4566 mL	46.9131 mL	117.2828 mL
	5 mM	0.9383 mL	4.6913 mL	9.3826 mL	23.4566 mL
	10 mM	0.4691 mL	2.3457 mL	4.6913 mL	11.7283 mL
	15 mM	0.3128 mL	1.5638 mL	3.1275 mL	7.8189 mL
	20 mM	0.2346 mL	1.1728 mL	2.3457 mL	5.8641 mL
	25 mM	0.1877 mL	0.9383 mL	1.8765 mL	4.6913 mL
	30 mM	0.1564 mL	0.7819 mL	1.5638 mL	3.9094 mL
	40 mM	0.1173 mL	0.5864 mL	1.1728 mL	2.9321 mL
	50 mM	0.0938 mL	0.4691 mL	0.9383 mL	2.3457 mL
	60 mM	0.0782 mL	0.3909 mL	0.7819 mL	1.9547 mL
	80 mM	0.0586 mL	0.2932 mL	0.5864 mL	1.4660 mL
	100 mM	0.0469 mL	0.2346 mL	0.4691 mL	1.1728 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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SDH-IN-2

Anti-Infection Compound Library

Antifungal Compound Library

Anti-Cancer Metabolism Compound Library

Mitochondria-Targeted Compound Library

Glucose Metabolism Compound Library

Metabolic Enzyme Compound Library

TCA Cycle Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Alkyne Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SDH-IN-2

Anti-Infection Compound Library

Antifungal Compound Library

Anti-Cancer Metabolism Compound Library

Mitochondria-Targeted Compound Library

Glucose Metabolism Compound Library

Metabolic Enzyme Compound Library

TCA Cycle Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Alkyne Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SDH-IN-2 Related Classifications

HY-148921 Related Classifications