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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
71 Results for "
OX2-R
" in MedChemExpress (MCE) Product Catalog:
Products (71)
71 Results for "OX2-R" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: Hypocretin-1 (human, rat, mouse)
Target:
Forschungsgebiete:
14
14 Publications Verification
Art. -Nr.: HY-106224B
Reinheit: 99.93%
Synonyms: Hypocretin-1 (human, rat, mouse) acetate
Target:
Forschungsgebiete:
14
14 Publications Verification
Art. -Nr.: HY-106224A
Reinheit: 97.13%
Synonyms: Hypocretin-1 (human, rat, mouse) TFA
Target:
Forschungsgebiete:
4
4 Cited Publications
Synonyms: JNJ-42847922
Target:
Forschungsgebiete:
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
4
4 Cited Publications
Synonyms: JNJ-42847922 hydrochloride
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Forschungsgebiete:
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
3
3 Cited Publications
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Forschungsgebiete:
TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1 [2].
3
3 Cited Publications
Art. -Nr.: HY-19914
CAS. Nr.: 1207253-08-4
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Forschungsgebiete:
MK-1064 is a selective and orally active OX2R antagonist (Ki: 0.5 nM, IC50: 18 nM). MK-1064 promotes sleep in vivo. MK-1064 can be used in the research of insomnia .
2
2 Cited Publications
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Forschungsgebiete:
JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist, with a pKi of 8.3. JNJ-10397049 is 600-fold selective for the OX2R over the OX1R [2].
2
Target:
Forschungsgebiete:
1
1 Cited Publications
Target:
Forschungsgebiete:
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models [2].
1
1 Cited Publications
Target:
Forschungsgebiete:
YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models [2].
1
1 Cited Publications
Target:
Forschungsgebiete:
IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.
Art. -Nr.: HY-159835
CAS. Nr.: 2460722-04-5
Synonyms: TAK-861
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Forschungsgebiete:
Oveporexton (TAK-861) is an orally active and selective orexin receptor 2 (OX2R) agonist with an EC50 of 2.5 nM. Oveporexton exhibits 3000-fold selectivity for OX2R over OX1R. Oveporexton can be used for the study of hypersomnia disorders including narcolepsy [2].
Synonyms: ORN-0829; TS-142
Target:
Forschungsgebiete:
Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia research research.
Synonyms: TAK-925
Target:
Forschungsgebiete:
Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms [2] .
Art. -Nr.: HY-19320
CAS. Nr.: 1796565-52-0
Target:
Forschungsgebiete:
Orexin 2 Receptor Agonist is a potent selective OX2R agonist with an EC50 of 23 nM .
Art. -Nr.: HY-172412
CAS. Nr.: 2648347-56-0
Synonyms: ALKS 2680
Target:
Forschungsgebiete:
Alixorexton (ALKS 2680) is an orally bioavailable, blood-brain barrier-permeable OX2R-selective activator and wake-promoting agent. Alixorexton can be used for the research of narcolepsy and idiopathic hypersomnia .
Synonyms: YZJ-1139
Target:
Forschungsgebiete:
Fazamorexant (YZJ-1139) is an orally active dual orexin receptor antagonist, with an IC50 of 32 nM against OX1R and an IC50 of 41 nM against OX2R. Fazamorexant prolongs total sleep time and improves sleep efficiency. Fazamorexant is applicable to related research on insomnia [2].
Synonyms: TAK-994
Target:
Forschungsgebiete:
Firazorexton hydrate (TAK-994) is an orally active and brain-penetrant orexin type 2 receptor (OX2R) selective agonist. Firazorexton hydrate can promote wakefulness and has the potential to improve narcolepsy-like symptoms in mice .
Art. -Nr.: HY-162235
CAS. Nr.: 1803557-42-7
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Forschungsgebiete:
CVN766 is an orally active inhibitor of orexin 1 receptor antagonist with blood-brain permeability with the IC50 values of 8 nM and >10 μM for OX1R and OX2R, respectively. CVN766 can be used for study schizophrenia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
