2305750-24-5
Chemical Structure
(R)-Adibelivir
Synonym(s): (R)-IM-250
- CAS No.: 2305750-24-5
- Formula:C20H19F2N3O2S2
- Molecular Weight:435.51
InChIKey: JDZTWDISDHLKCR-GDLZYMKVSA-N
SMILES: FC(C=CC(F)=C1)=C1C(C=C2)=CC=C2CC(N(C3=NC(C)=C([S@](C)(=N)=O)S3)C)=O
Biological Activity: (R)-Adibelivir ((R)-IM-250) is a blood-brain barrier-permeable HSV helicase-primase inhibitor. (R)-Adibelivir specifically inhibits the activity of the HSV UL5-UL52-UL8 helicase-primase complex. (R)-Adibelivir affects viral reactivation and significantly reduces the reactivation capacity of latent neuronal HSV reservoirs. (R)-Adibelivir can be used in studies related to herpes simplex virus infection, herpes encephalitis, neonatal herpes, and other related conditions[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(R)-Adibelivir | 99.97% | (R)-Adibelivir ((R)-IM-250) is a blood-brain barrier-permeable HSV helicase-primase inhibitor. (R)-Adibelivir specifically inhibits the activity of the HSV UL5-UL52-UL8 helicase-primase complex. (R)-Adibelivir affects viral reactivation and significantly reduces the reactivation capacity of latent neuronal HSV reservoirs. (R)-Adibelivir can be used in studies related to herpes simplex virus infection, herpes encephalitis, neonatal herpes, and other related conditions. | ||||||||||||||||||||
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References
- [1]. Sarvari G, et al. Structure, Function and Inhibition of Helicases Involved in Virus Infection. Biomolecules. 2026;16(2):273. Published 2026 Feb 9. [Content Brief]
- [2]. Gege C, et al. Structural determinants of nervous system exposure of adibelivir (IM-250) and related herpes helicase-primase inhibitors across animal species. Antiviral Res. 2025;243:106271. [Content Brief]
- [3]. Bay C, et al. A UPLC-MS/MS assay for the quantification of the novel viral helicase-primase drug candidate adibelivir (IM-250) in human specimen. J Chromatogr B Analyt Technol Biomed Life Sci. 2026;1275:124995. [Content Brief]
