SOX17 - SRY-box transcription factor 17 Gene

Also Known as VUR3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64321

About SOX17

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:54,457,935-54,460,892 (from NCBI)

This gene has 1 transcript (splice variant), 199 orthologues, 20 paralogues and is associated with 3 phenotypes. Broad expression in endometrium (RPKM 12.0), fat (RPKM 9.8) and 14 other tissues.

Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with Other proteins. [provided by RefSeq, Jul 2008]

SOX17 Products (1)

mRNA	Protein	Name
NM_022454.4	NP_071899.1	transcription factor SOX-17

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17875931	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	17875931	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17875931	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac cell fate determination	IMP IMP: Inferred from mutant phenotype	19736317	GOA
involved in endoderm formation	IDA IDA: Inferred from direct assay	18682240	GOA
involved in metanephros development	IMP IMP: Inferred from mutant phenotype	20960469	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18413743	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18413743	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22292085	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	17875931	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	17875931	GOA
involved in ureter development	IMP IMP: Inferred from mutant phenotype	20960469	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17875931	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	19736317	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOX17 Protein Structure

HMG_box

Sox17_18_mid

0
100
200
300
414 a.a.

Protein Preferred Names	Protein Names
transcription factor SOX-17	SRY (sex determining region Y)-box 17

SOX17 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SOX17	Q9H6I2	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	17875931

Cross: Cross-species interaction Intra: Intraspecies interaction

SOX17 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81454	SOX17 Antibody (YA1199)	IHC-P	Human
HY-P81454A	SOX17 Antibody (YA1199)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Vesicoureteral Reflux 3	VUR3
Familial Vesicoureteral Reflux	Familial Vur
Pulmonary Hypertension, Primary, 1	Pulmonary Arterial Hypertension Pah Idiopathic Pulmonary Arterial Hypertension Idiopathic Pulmonary Hypertension Primary Pulmonary Hypertension PPH1 Pulmonary Hypertension, Primary, Fenfluramine Or Dexfenfluramine-Associated Pulmonary Hypertension, Familial Primary, 1, With Or Without Hht Pph Familial Primary Pulmonary Hypertension Sporadic Primary Pulmonary Hypertension Pht Fpah Familial Pulmonary Arterial Hypertension Hereditary Pulmonary Arterial Hypertension Heritable Pulmonary Arterial Hypertension Ayerza Syndrome Fpph Ppht Ipah Primary Pulmonary Arterial Hypertension Pulmonary Hypertension, Familial Primary Hypertension, Pulmonary, Primary, Type 1 Ayerza'S Syndrome Pah - [Pulmonary Arterial Hypertension] Arrillaga Ayerza Syndrome
Adenocarcinoma In Situ
Seminoma	Seminoma, Pure
Vesicoureteral Reflux	Vesico-Ureteral Reflux
Biliary Atresia	Congenital Biliary Atresia Isolated Biliary Atresia Isolated Atresia Of Bile Ducts Non-Syndromic Biliary Atresia Atresia Of Bile Duct Biliary Atresia, Congenital Atresia Of Bile Ducts Bile Duct Atresia Congenital Bile Duct Atresia Ba - [Biliary Atresia] Impervious Bile Duct Atresia Of Common Duct Biliary Duct Atresia Bile Ductal Atresia Cystic Duct Atresia
Hypotrichosis-Lymphedema-Telangiectasia Syndrome	HLTS Hypotrichosis Lymphedema Telangiectasia Syndrome Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Uterine Corpus Endometrial Carcinoma
Germ Cell And Embryonal Cancer	Germ Cell And Embryonal Neoplasm
Mixed Germ Cell Cancer	Mixed Germ Cell Tumor Mixed Germ Cell Neoplasm Mixed Germ Cell Tumour Mixed Teratoma And Seminoma
Germ Cell Cancer	Malignant Germ Cell Tumor Neoplasms, Germ Cell And Embryonal Germ Cell Neoplasm Germ Cell Tumour Malignant Tumor Of The Germ Cell Neoplasms Germ Cell Malignant Germ Cell Neoplasm
Squamous Cell Papilloma	Papilloma Epidermoid Papilloma Papilloma, Squamous Cell
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Pulmonary Venoocclusive Disease	Pulmonary Veno-Occlusive Disease Obstructive Disease Of The Pulmonary Veins Pvod Isolated Pulmonary Venous Sclerosis Venous Form Of Primary Pulmonary Hypertension Pulmonary Venoocclusive Disease 1, Autosomal Dominant
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Cerebral Arterial Disease	Cerebral Arterial Diseases
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 4	PEOA4 Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 4 Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 4 Chronic Progressive External Ophthalmoplegia Progressive External Ophthalmoplegia, Autosomal Dominant 4 Autosomal Dominant Progressive External Ophthalmoplegia 4 Cpeo Graefe Disease Mitochondrial Ocular Myopathy Ocular Myopathy Of Von Graefe-Fuchs Progressive External Ophthalmoplegia Autosomal Dominant 4 Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 4 Kearns-Sayre Syndrome
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116940	Sm4	Inhibitor	99.01%	Unkown
HY-161024	AC1Q3QWB	Inhibitor	99.39%	Unkown
HY-RS20493	Sox17 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13589	SOX17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27001	Sox17 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SOX17	MGD	MGI:107543
Canis familiaris	SOX17	VGNC	VGNC:46676
Rattus norvegicus	SOX17	RGD	RGD:1305371
Bos taurus	SOX17	VGNC	VGNC:35144
Macaca mulatta	SOX17	VGNC	VGNC:104497
Others	SOX17	NCBI