IND8
IND8 is a α7 nAChR activator and cognitive enhancer. IND8 mediates cognitive enhancement by activating α7 nAChR . IND8 improves spatial working memory, episodic short-term memory and spatial long-term memory in amnesic mice induced by Scopolamine (HY-N0296). IND8 improves memory function in mice with delayed natural memory decline. IND8 can be used in research related to Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 1778682-59-9
- Formula: C17H19N5
- Molecular Weight:293.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IND8 potently binds to and activates α7-nAChRs in cells expressing LGIC receptors, with a Kd of 0.12 μM and an EC50 of 0.03 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
IND8 (10-25 μmol/kg; intraperitoneal injection; single administration) improves cognitive function in mice with delayed-induced natural memory decline[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, 6-weeks of age, scopolamine-induced amnesia)[1]
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Dosage:5 μmol/kg (1.5 mg/kg); 10 μmol/kg (2.9 mg/kg); 25 μmol/kg (7.3 mg/kg); 50 μmol/kg (14.7 mg/kg)
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Administration:i.p.; single dose
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Result:Significantly reversed scopolamine-induced cognitive deficit, with percentage of unfamiliar arm exploration significantly higher than the scopolamine-treated group.
Increased discrimination index (DI) at 10 μmol/kg and 50 μmol/kg compared to the scopolamine-treated group, and exploration time of the novel object was significantly longer than the familiar object.
Increased time spent in the target quadrant at 25 μmol/kg and 50 μmol/kg compared to the scopolamine-treated group.
Chemical Information
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CAS No. 1778682-59-9
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Molecular Weight 293.37
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Formula C17H19N5
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SMILES
N1(C2CN3CCC2CC3)N=NC(C4=CC5=C(NC=C5)C=C4)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IND8 Related Classifications
HY-116488 Related Classifications
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