105637-38-5
105637-38-5
Chemical Structure
(S,S)-Z-FA-FMK
- CAS No.: 105637-38-5
- Formula:C21H23FN2O4
- Molecular Weight:386.42
IUPAC Name: benzyl ((S)-1-(((S)-4-fluoro-3-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
InChIKey: ASXVEBPEZMSPHB-YJBOKZPZSA-N
SMILES: O=C(OCC1=CC=CC=C1)N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(CF)=O)=O
Biological Activity: (S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position[1][2].
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(S,S)-Z-FA-FMK | (S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position. | |||||||||||||||||||||
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References
- [1]. Koike S, et al. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. Int J Mol Sci. 2016;17(9):1567. Published 2016 Sep 16. [Content Brief]
- [2]. Harrison JS, et al. The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts. Oncotarget. 2016;7(24):36447-36460. [Content Brief]
