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Cat. No.: HY-139032

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CM121

Name: CM121
Brand: MedChemExpress
SKU: HY-139032
Price: 660.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC₅₀=0.54 μM；Kd=1.1 μM) with a variety of hydrophobic interactions.

For research use only. We do not sell to patients.

Purity : 99.95%
CAS No.: 2204230-40-8
Formula: C₂₄H₁₇FN₄O₃S
Molecular Weight:460.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CM121 Chemical Structure

CAS No.: 2204230-40-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC₅₀=0.54 μM；Kd=1.1 μM) with a variety of hydrophobic interactions^[1].

IC₅₀ & Target

IC50: 0.54 μM (ALDH1A2), Kd: 1.1 μM (ALDH1A2)^[1]

All Aldehyde Dehydrogenase (ALDH) Isoforms :

In Vitro

CM121 interacts with the main-chain amides of Cys320 and Thr321 and the side-chains of Thr321 and Asn187 via methylsulfonyl oxygen. CM121 establishes π-π stacking with the side chains of PHE188 and PHE314 through methylsulfonyl benzene and benzylonitrile rings^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2204230-40-8
Appearance Solid
Molecular Weight 460.48
Formula C₂₄H₁₇FN₄O₃S
Color White to off-white
SMILES

O=C(C1=CN(C2=CC=C(C#N)C=C2)N=C1C3=CC=C(S(=O)(C)=O)C=C3)NC4=CC=CC(F)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (10.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1716 mL

10.8582 mL

21.7165 mL

5 mM

0.4343 mL

2.1716 mL

4.3433 mL

10 mM

0.2172 mL

1.0858 mL

2.1716 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen Y, et al. Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors. ACS Chem Biol. 2018;13(3):582-590

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1716 mL	10.8582 mL	21.7165 mL	54.2912 mL
	5 mM	0.4343 mL	2.1716 mL	4.3433 mL	10.8582 mL
	10 mM	0.2172 mL	1.0858 mL	2.1716 mL	5.4291 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

CM121

All Aldehyde Dehydrogenase (ALDH) Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Solvent & Solubility

In Vitro:

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

CM121 Related Classifications

HY-139032 Related Classifications

Bioz

Keywords

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