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Cat. No.: HY-179088

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AVI-6451

AVI-6451 is a novel orally effective SARS-CoV-2 Mac1 (IC₅₀ = 28 nM) inhibitor. AVI-6451 can reduce viral load. AVI-6451 can be used for research on viral infections.

For research use only. We do not sell to patients.

CAS No.: 3105043-06-6
Formula: C₁₈H₁₈FN₅O₂
Molecular Weight:355.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

AVI-6451 Chemical Structure

CAS No.: 3105043-06-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

AVI-6451 is a novel orally effective SARS-CoV-2 Mac1 (IC₅₀ = 28 nM) inhibitor. AVI-6451 can reduce viral load. AVI-6451 can be used for research on viral infections^[1].

Chemical Information

CAS No. 3105043-06-6
Molecular Weight 355.37
Formula C₁₈H₁₈FN₅O₂
SMILES

O=C1OCC(C)(C)N1NC2=C3C(NC4=C3C=C(F)C=C4C5CC5)=NC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jaishankar P, et al. Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo[J]. bioRxiv, 2025: 2025.10. 11.681833.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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