BCN-exo-PEG7-maleimide
Based on 1 Customer Validation
BCN-exo-PEG7-maleimide is an ADC Linker containing 7 PEG units. BCN-exo-PEG7-maleimide contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
For research use only. We do not sell to patients.
- CAS No.: 2143965-47-1
- Formula: C34H53N3O12
- Molecular Weight:695.80
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
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Help & FAQs
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HY-156322
BCN-exo-PEG3-maleimideADC Linker -
HY-133400
endo-BCN-PEG3-malPROTAC linker -
HY-W111141
BCN-OHBCN-TPP Probe Control -
HY-140070
endo-BCN-PEG8-NHS esterPROTAC Linker -
HY-43581
endo-BCN-O-PNBPROTAC Linker -
HY-133406
exo BCN-O-PNBPROTAC Linker -
HY-W096149
exo-BCN-NHS carbonateClick Chemistry Reagent -
HY-140077
endo-BCN-PEG3-NH-BocPROTAC Linker -
HY-140065
endo-BCN-PEG8-acidPROTAC linker
Biological Activity
Description
Chemical Information
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CAS No. 2143965-47-1
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Appearance Oil
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Molecular Weight 695.80
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Formula C34H53N3O12
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Color Off-white to light yellow
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SMILES
O=C(C=CC1=O)N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCNC(OC[C@H]2[C@@]3([H])[C@]2([H])CCC#CCC3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Protocols
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EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Purity & Documentation
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Data Sheet (236 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BCN-exo-PEG7-maleimide Related Classifications
HY-134734 Related Classifications
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