2. PROTAC
  3. PROTAC Linkers
  4. Benzyl-PEG12-alcohol

Benzyl-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Benzyl-PEG12-alcohol

Benzyl-PEG12-alcohol Chemical Structure

CAS No. : 2218463-17-1

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Based on 1 publication(s) in Google Scholar

Benzyl-PEG12-alcohol Related Antibodies

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Description

Benzyl-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Benzyl-PEG12-alcohol Related Antibodies
Molecular Weight

636.77

Formula

C31H56O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC1=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (196.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5704 mL 7.8521 mL 15.7043 mL
5 mM 0.3141 mL 1.5704 mL 3.1409 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5704 mL 7.8521 mL 15.7043 mL 39.2606 mL
5 mM 0.3141 mL 1.5704 mL 3.1409 mL 7.8521 mL
10 mM 0.1570 mL 0.7852 mL 1.5704 mL 3.9261 mL
15 mM 0.1047 mL 0.5235 mL 1.0470 mL 2.6174 mL
20 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9630 mL
25 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5704 mL
30 mM 0.0523 mL 0.2617 mL 0.5235 mL 1.3087 mL
40 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL
50 mM 0.0314 mL 0.1570 mL 0.3141 mL 0.7852 mL
60 mM 0.0262 mL 0.1309 mL 0.2617 mL 0.6543 mL
80 mM 0.0196 mL 0.0982 mL 0.1963 mL 0.4908 mL
100 mM 0.0157 mL 0.0785 mL 0.1570 mL 0.3926 mL
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Benzyl-PEG12-alcohol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzyl-PEG12-alcohol2218463-17-1PROTAC LinkersInhibitorinhibitorinhibit

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